ReviewSpinal cord2019
Guidelines for the conduct of clinical trials in spinal cord injury: Neuroimaging biomarkers.
Review in Spinal cord, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Brain MRI changes in degenerative cervical myelopathy: a systematic review.EBioMedicine · 2024Pooled it
- Fighting for recovery on multiple fronts: The past, present, and future of clinical trials for spinal cord injury.Frontiers in cellular neuroscience · 2022Pooled it
- Development of a predictive model for postoperative erectile function recovery in male patients with incomplete traumatic cervical spinal cord injury.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Spinal Cord Radiomics-Driven Machine Learning Predicts Meaningful Clinical Improvement After Surgery for Degenerative Cervical Myelopathy: A Pilot Study.Journal of imaging informatics in medicine · 2026Article
- Differential brain reorganization in chronic cervical spinal cord injury and its relation to motor versus sensory impairments: a preliminary investigation.Scientific reports · 2026Article
- Metabolic and Structural Alterations in the Motor System Following Spinal Cord Injury: An In-VivoJournal of neuroscience research · 2025Article
- Remote neurodegeneration in the lumbosacral cord one month after spinal cord injury: a cross-sectional MRI study.Annals of clinical and translational neurology · 2025Article
- SynSpine: an automated workflow for the generation of longitudinal spinal cord synthetic MRI data.Frontiers in neuroinformatics · 2025Article
- Progressive Remote Axonal Degeneration Following Spinal Cord Injury: A Histological and MRI Study.Neurotrauma reports · 2025Article
- Exploring the Landscape of Biomarkers in Spinal Cord Injury.Topics in spinal cord injury rehabilitation · 2025Review
- Utilizing multimodal radiomics technology from cervical MRI for diagnosis of cervical spinal cord injury and spinal cord concussion.Scientific reports · 2024Article
- Neurodegeneration within the rostral spinal cord is associated with brain gray matter volume atrophy in the early stage of cervical spondylotic myelopathy.Spinal cord · 2024Article
- Longitudinal motor system changes from acute to chronic spinal cord injury.European journal of neurology · 2024Article
- Optimization of cervical cord synthetic TImaging neuroscience (Cambridge, Mass.) · 2024Article
- Article
- Neuroinflammation in the Evolution of Motor Function in Stroke and Trauma Patients: Treatment and Potential Biomarkers.Current issues in molecular biology · 2023Review
- Longitudinal multiparametric MRI of traumatic spinal cord injury in animal models.Magnetic resonance imaging · 2023Review
- Transplantation of Chemical Compound-Induced Cells from Human Fibroblasts Improves Locomotor Recovery in a Spinal Cord Injury Rat Model.International journal of molecular sciences · 2023Article
- Hindlimb muscle spindles inform preparatory forelimb coordination prior to landing in toads.The Journal of experimental biology · 2023Article
- Biomarkers for predicting the severity of spinal cord injury by proteomic analysis.Frontiers in molecular neuroscience · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Traumatic spinal cord injury (SCI) leads to immediate neuronal and axonal damage at the focal injury site and triggers secondary pathologic series of events resulting in sensorimotor and autonomic dysfunction below the level of injury. Although there is no cure for SCI, neuroprotective and regenerative therapies show promising results at the preclinical stage. There is a pressing need to develop non-invasive outcome measures that can indicate whether a candidate therapeutic agent or a cocktail of therapeutic agents are positively altering the underlying disease processes. Recent conventional MRI studies have quantified spinal cord lesion characteristics and elucidated their relationship between severity of injury to clinical impairment and recovery. Next to the quantification of the primary cord damage, quantitative MRI measures of spinal cord (rostrocaudally to the lesion site) and brain integrity have demonstrated progressive and specific neurodegeneration of afferent and efferent neuronal pathways. MRI could therefore play a key role to ultimately uncover the relationship between clinical impairment/recovery and injury-induced neurodegenerative changes in the spinal cord and brain. Moreover, neuroimaging biomarkers hold promises to improve clinical trial design and efficiency through better patient stratification. The purpose of this narrative review is therefore to propose a guideline of clinically available MRI sequences and their derived neuroimaging biomarkers that have the potential to assess tissue damage at the macro- and microstructural level after SCI. In this piece, we make a recommendation for the use of key MRI sequences-both conventional and advanced-for clinical work-up and clinical trials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.