ArticleScientific reports2019
Diffraction-limited axial scanning in thick biological tissue with an aberration-correcting adaptive lens.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed, 30 citations in OpenAlex.
- Cellpose3: one-click image restoration for improved cellular segmentation.Nature methods · 2025Article
- Patient-Specific Vascularized Tumor Model: Blocking TAM Recruitment with Multispecific Antibodies Targeting CCR2 and CSF-1R.bioRxiv : the preprint server for biology · 2023Article
- Two-photon scanned light sheet fluorescence microscopy with axicon imaging for fast volumetric imaging.Journal of biomedical optics · 2021Article
- Video-rate remote refocusing through continuous oscillation of a membrane deformable mirror.JPhys photonics · 2021Article
- Reduction of spherical and chromatic aberration in axial-scanning optical systems with tunable lenses.Biomedical optics express · 2021Article
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Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diffraction-limited deep focusing into biological tissue is challenging due to aberrations that lead to a broadening of the focal spot. The diffraction limit can be restored by employing aberration correction for example with a deformable mirror. However, this results in a bulky setup due to the required beam folding. We propose a bi-actuator adaptive lens that simultaneously enables axial scanning and the correction of specimen-induced spherical aberrations with a compact setup. Using the bi-actuator lens in a confocal microscope, we show diffraction-limited axial scanning up to 340 μm deep inside a phantom specimen. The application of this technique to in vivo measurements of zebrafish embryos with reporter-gene-driven fluorescence in a thyroid gland reveals substructures of the thyroid follicles, indicating that the bi-actuator adaptive lens is a meaningful supplement to the existing adaptive optics toolset.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.