Evidence map›Paper›PMID 31267004›Full record

ArticleScientific reports2019

Stargazin and γ4 slow the channel opening and closing rates of GluA4 AMPA receptors.

Vincen D Pierce, Li Niu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Vincen D PierceDepartment of Chemistry, and Center for Neuroscience Research, University at Albany, SUNY, Albany, New York, 12222, United States.
Li NiuDepartment of Chemistry, and Center for Neuroscience Research, University at Albany, SUNY, Albany, New York, 12222, United States. lniu@albany.edu.
University at Albany, State University of New York · US

Funding

Mechanistic studies of the GYKI CompoundsR01NS060812 · NINDS · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI NIU, LI · 2009 to 2013
$1.5M
Testing RNA Aptamers in ALS Mouse ModelsR21NS106392 · NINDS · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI NIU, LI · 2018 to 2019
$406k
NINDS NIH HHS R01 NS060812NINDS NIH HHS R21 NS106392
6 · The paper itself

Abstract

As auxiliary subunits, transmembrane AMPA receptor regulatory proteins (TARPs) are known to enhance macroscopic current amplitude and alter kinetic properties of AMPA receptors on slow time scale, such as desensitization rate. Whether TARPs affect the rate of AMPA channel opening and closing, however, remains elusive. Using a laser-pulse photolysis technique, we investigated the effect of γ-2 (stargazin, a type 1a TARP) and γ-4 (a type 1b TARP) on the channel-opening and channel-closing rate constants (i.e., k

Indexed as

Ion Channel GatingCalcium ChannelsCell LineDose-Response Relationship, DrugGene ExpressionGlutamic AcidHumansReceptors, AMPACACNG2 protein, humanCalcium ChannelsGlutamic AcidReceptors, AMPA

Identifiers

PMID31267004
PMCPMC6606765
OpenAlexW2954100969

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.