ArticleScientific reports2019
Extracellular matrix stiffness regulates human airway smooth muscle contraction by altering the cell-cell coupling.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Multiscale metabolic mapping of lung tissue via coregistered mass spectrometry and nonlinear optical imaging.Science advances · 2026Article
- Dysfunction of PDE4DIP contributes to LVNC development by regulating cell polarity, skeleton, and energy metabolism via Rho-ROCK pathway.Genes & diseases · 2025Article
- A multimodal imaging approach for imaging the metabolic changes resulting from bronchopulmonary dysplasia.bioRxiv : the preprint server for biology · 2025Article
- N-cadherin antagonism is bronchoprotective in severe asthma models.Science advances · 2024Article
- Mapping the unicellular transcriptome of the ascending thoracic aorta to changes in mechanosensing and mechanoadaptation during aging.Aging cell · 2024Article
- Spatio-temporal Relationship between Three-Dimensional Deformations of a Collapsible Tube and the Downstream Flowfield.Journal of fluids and structures · 2024Article
- Nuclear curvature determines Yes-associated protein localization and differentiation of mesenchymal stem cells.Biophysical journal · 2024Article
- Mechanobiology of Type 1 hypersensitivity: Elucidating the impacts of mechanical forces in allergic reactions.Mechanobiology in medicine · 2024Review
- Proteomic analysis reveals LRPAP1 as a key player in the micropapillary pattern metastasis of lung adenocarcinoma.Heliyon · 2024Article
- Long-term effects of vaginal surgery and endogenous ovarian hormones on the vagina and bladder.Sexual medicine · 2023Article
- Downregulation of YAP Activity Restricts P53 Hyperactivation to Promote Cell Survival in Confinement.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Development of a novel air-liquid interface airway tissue equivalent model for in vitro respiratory modeling studies.Scientific reports · 2023Article
- Regulation of oxytocin-induced calcium transients and gene expression in engineered myometrial tissues by tissue architecture and matrix rigidity.Current research in physiology · 2023Article
- Inherent differences of small airway contraction and CaFrontiers in cell and developmental biology · 2023Article
- Contribution of mechanical homeostasis to epithelial-mesenchymal transition.Cellular oncology (Dordrecht, Netherlands) · 2022Review
- Supracellular measurement of spatially varying mechanical heterogeneities in live monolayers.Biophysical journal · 2022Article
- Lysyl oxidase like 2 is increased in asthma and contributes to asthmatic airway remodelling.The European respiratory journal · 2022Article
- Muscarinic receptor M3 activation promotes fibrocytes contraction.Frontiers in pharmacology · 2022Article
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Authors and funding
6 authors.
Funding
Abstract
For an airway or a blood vessel to narrow, there must be a connected path that links the smooth muscle (SM) cells with each other, and transmits forces around the organ, causing it to constrict. Currently, we know very little about the mechanisms that regulate force transmission pathways in a multicellular SM ensemble. Here, we used extracellular matrix (ECM) micropatterning to study force transmission in a two-cell ensemble of SM cells. Using the two-SM cell ensemble, we demonstrate (a) that ECM stiffness acts as a switch that regulates whether SM force is transmitted through the ECM or through cell-cell connections. (b) Fluorescent imaging for adherens junctions and focal adhesions show the progressive loss of cell-cell borders and the appearance of focal adhesions with the increase in ECM stiffness (confirming our mechanical measurements). (c) At the same ECM stiffness, we show that the presence of a cell-cell border substantially decreases the overall contractility of the SM cell ensemble. Our results demonstrate that connectivity among SM cells is a critical factor to consider in the development of diseases such as asthma and hypertension.
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