Evidence map›Paper›PMID 31266993›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2019

Results of full postmortem examination in a cohort of clinically unexplained stillbirths: undetected fetal growth restriction and placental insufficiency are prevalent findings.

Claire Blythe, Rita E Zapata Vazquez, Maria S Cabrera, Sandra Zekic Tomas, Dilly Oc Anumba, Marta C Cohen

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In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Placental Pathology Findings in Unexplained Pregnancy Losses.Reproductive sciences (Thousand Oaks, Calif.) · 2024
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 4 countries.

Claire BlytheDepartment of Paediatrics, Sheffield Children's NHS Foundation Trust, Western Bank, Sheffield, S10 2TH, UK.
Rita E Zapata VazquezFacultad de Medicina, Universidad Autónoma de Yucatán, Mérida, Mexico.
Maria S CabreraDepartment of Obstetrics and Gynaecology Department, Hospital Ramos Mejia, Buenos Aires, Argentina.
Sandra Zekic TomasHistopathology Department, Sheffield Children's NHS Trust, Western Bank, Sheffield, S10 2TH, UK.
Dilly Oc AnumbaDepartment of Obstetrics and Gynaecology, Reproductive and Developmental Medicine, The University of Sheffield, Sheffield, UK.
Marta C CohenHistopathology Department, Sheffield Children's NHS Trust, Western Bank, Sheffield, S10 2TH, UK. Marta.Cohen@nhs.net.ORCID http://orcid.org/0000-0001-5534-444X
Sheffield Children's NHS Foundation Trust · GBAutonomous University of Yucatán · MXHospital Ramos Mejía · ARUniversity of Sheffield · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo analyze a cohort of clinically unexplained stillbirths (CUS) referred for postmortem. STUDY

designIn total, 258 CUS were referred for full postmortem between 2009 and 2015. Relevant Condition at Death (ReCoDe) classification was applied. Statistical analysis included chi-square test and multiple logistic regression.

resultsIn all, 386 ReCoDe categories identified corresponded to: fetus (99); umbilical cord (48); placenta (165); amniotic fluid (55), and mother (1). No condition was identified in 18 cases. Prevalent conditions were placental insufficiency (101 cases, 39%) and fetal growth restriction (96 cases, 37%), frequently presenting together (41 cases, 15.9%). Significant associations were found between fetal growth restriction and gestational age, asymmetrical fetal growth and placental insufficiency.

conclusionsIn total, 60.5% of CUS were diagnosed at postmortem to have fetal growth restriction and/or placental insufficiency. The mean gestational age of death in which these conditions presented was 32.7 weeks and 35.5 weeks, respectively, suggesting a critical time-frame to monitor to potentially reduce stillbirth occurrence.

Indexed as

AutopsyStillbirthChorioamnionitisDiagnosisFemaleFetal Growth RetardationHumansLogistic ModelsPlacentaPlacental InsufficiencyPregnancyUmbilical Cord

Identifiers

PMID31266993
OpenAlexW2955692834

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.