ArticleScientific reports2019
Incidence and risk factors for Preeclampsia in a cohort of healthy nulliparous pregnant women: a nested case-control study.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07263490 (PRIOR Study), which is not on this map. Cited by 30 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
PRIOR Study (Pre-eclampsia Risk In Oocyte Recipients) - Investigating Matching, Biomarkers and Outcomes.
Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Effect of Hyperthyroidism Control During Pregnancy on Maternal and Fetal Outcome: A Systematic Review and Meta-Analysis.Frontiers in endocrinology · 2022Pooled it
- Systematic review supports the role of DNA methylation in the pathophysiology of preeclampsia: a call for analytical and methodological standardization.Biology of sex differences · 2020Pooled it
- Liver function monitoring: a prospective nested case-control study of Salvia miltiorrhiza polyphenol injection.Scientific reports · 2020Pooled it
- Magnesium supplementation and preeclampsia in low-income pregnant women - a randomized double-blind clinical trial.BMC pregnancy and childbirth · 2020Trial
- Risk Factors and Awareness of Preeclampsia Among Pregnant Women Attending Antenatal Care in Nasarawa State.Public health challenges · 2026Article
- Assessment of albumin-related inflammatory indices in preeclampsia and their relationship with composite adverse perinatal outcomes.BMC pregnancy and childbirth · 2026Article
- Evaluation of oxidative stress markers and the angiogenic factors in preeclampsia and associated features.BMC pregnancy and childbirth · 2025Article
- Relationship between food insecurity and the risk of pregnancy-induced hypertension: a prospective cohort study.BMC pregnancy and childbirth · 2025Article
- Hypertensive disorder prediction among first-trimester antenatal patients using Gestosis score.Bioinformation · 2025Article
- Advancing diagnosis and early risk assessment of preeclampsia through noninvasive cell-free DNA methylation profiling.Clinical epigenetics · 2024Article
- Hypertensive disorders during pregnancy as a major cause of preterm birth and adverse perinatal outcomes: findings from a Brazilian National Survey.Einstein (Sao Paulo, Brazil) · 2024Article
- RUPP Th17s cause hypertension and mitochondrial dysfunction in the kidney and placenta during pregnancy.Pregnancy hypertension · 2023Article
- Genetic Polymorphisms of Vascular Endothelial Growth Factor in Neonatal Pathologies: A Systematic Search and Narrative Synthesis of the Literature.Children (Basel, Switzerland) · 2023Review
- Preeclampsia: Recent Advances in Predicting, Preventing, and Managing the Maternal and Fetal Life-Threatening Condition.International journal of environmental research and public health · 2023Review
- B2 cells contribute to hypertension and natural killer cell activation possibly via AT1-AA in response to placental ischemia.American journal of physiology. Renal physiology · 2023Article
- Mouse models of preeclampsia with preexisting comorbidities.Frontiers in physiology · 2023Review
- Pre-pregnancy body mass index combined with peripheral blood PLGF, DCN, LDH, and UA in a risk prediction model for pre-eclampsia.Frontiers in endocrinology · 2023Article
- Soluble Epoxide Hydrolase Is Associated with Postprandial Anxiety Decrease in Healthy Adult Women.International journal of molecular sciences · 2022Article
- Proton Pump Inhibitors Use and Risk of Preeclampsia: A Meta-Analysis.Journal of clinical medicine · 2022Article
- Performances of birthweight charts to predict adverse perinatal outcomes related to SGA in a cohort of nulliparas.BMC pregnancy and childbirth · 2022Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this study is to determine the incidence, socio-demographic and clinical risk factors for preeclampsia and associated maternal and perinatal adverse outcomes. This is a nested case-control derived from the multicentre cohort study Preterm SAMBA, in five different centres in Brazil, with nulliparous healthy pregnant women. Clinical data were prospectively collected, and risk factors were assessed comparatively between PE cases and controls using risk ratio (RR) (95% CI) plus multivariate analysis. Complete data were available for 1,165 participants. The incidence of preeclampsia was 7.5%. Body mass index determined at the first medical visit and diastolic blood pressure over 75 mmHg at 20 weeks of gestation were independently associated with the occurrence of preeclampsia. Women with preeclampsia sustained a higher incidence of adverse maternal outcomes, including C-section (3.5 fold), preterm birth below 34 weeks of gestation (3.9 fold) and hospital stay longer than 5 days (5.8 fold) than controls. They also had worse perinatal outcomes, including lower birthweight (a mean 379 g lower), small for gestational age babies (RR 2.45 [1.52-3.95]), 5-minute Apgar score less than 7 (RR 2.11 [1.03-4.29]), NICU admission (RR 3.34 [1.61-6.9]) and Neonatal Near Miss (3.65 [1.78-7.49]). Weight gain rate per week, obesity and diastolic blood pressure equal to or higher than 75 mmHg at 20 weeks of gestation were shown to be associated with preeclampsia. Preeclampsia also led to a higher number of C-sections and prolonged hospital admission, in addition to worse neonatal outcomes.
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