ArticleScientific reports2019
In vivo magnetic resonance imaging of treatment-induced apoptosis.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
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- Detection of Treatment Response in Triple-Negative Breast Tumors to Paclitaxel Using MRI Cell Size Imaging.Journal of magnetic resonance imaging : JMRI · 2024Article
- Diffusion time dependency of extracellular diffusion.Magnetic resonance in medicine · 2023Article
- Improving MR cell size imaging by inclusion of transcytolemmal water exchange.NMR in biomedicine · 2022Article
- Shortwave-infrared (SWIR) emitting annexin V for high-contrast fluorescence molecular imaging of tumor apoptosis in living mice.RSC advances · 2022Article
- In Vitro and In Vivo Fluorescence Imaging of Antibody-Drug Conjugate-Induced Tumor Apoptosis Using Annexin V-EGFP Conjugated Quantum Dots.ACS omega · 2022Article
- MR cell size imaging with temporal diffusion spectroscopy.Magnetic resonance imaging · 2021Review
- Probing neural tissues at small scales: Recent progress of oscillating gradient spin echo (OGSE) neuroimaging in humans.Journal of neuroscience methods · 2021Article
- MRI-cytometry: Mapping nonparametric cell size distributions using diffusion MRI.Magnetic resonance in medicine · 2021Article
- Mapping hepatocyte size in vivo using temporal diffusion spectroscopy MRI.Magnetic resonance in medicine · 2020Article
- Dual-colour (near-infrared/visible) emitting annexin V for fluorescence imaging of tumour cell apoptosisRSC advances · 2020Article
- MRI of tumor T cell infiltration in response to checkpoint inhibitor therapy.Journal for immunotherapy of cancer · 2020Article
- Magnetic resonance imaging of mean cell size in human breast tumors.Magnetic resonance in medicine · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Imaging apoptosis could provide an early and specific means to monitor tumor responses to treatment. To date, despite numerous attempts to develop molecular imaging approaches, there is still no widely-accepted and reliable method for in vivo imaging of apoptosis. We hypothesized that the distinct cellular morphologic changes associated with treatment-induced apoptosis, such as cell shrinkage, cytoplasm condensation, and DNA fragmentation, can be detected by temporal diffusion spectroscopy imaging (TDSI). Cetuximab-induced apoptosis was assessed in vitro and in vivo with cetuximab-sensitive (DiFi) and insensitive (HCT-116) human colorectal cancer cell lines by TDSI. TDSI findings were complemented by flow cytometry and immunohistochemistry. Cell cycle analysis and flow cytometry detected apoptotic cell shrinkage in cetuximab-treated DiFi cells, and significant apoptosis was confirmed by histology. TDSI-derived parameters quantified key morphological changes including cell size decreases during apoptosis in responsive tumors that occurred earlier than gross tumor volume regression. TDSI provides a unique measurement of apoptosis by identifying cellular characteristics, particularly cell shrinkage. The method will assist in understanding the underlying biology of solid tumors and predict tumor response to therapies. TDSI is free of any exogenous agent or radiation, and hence is very suitable to be incorporated into clinical applications.
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Registered trials
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