ArticleNature communications2019
Essentiality of sterol synthesis genes in the planctomycete bacterium Gemmata obscuriglobus.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Origin and transport of bacterial hopanoids.mSystems · 2026Article
- Microbe Profile:Microbiology (Reading, England) · 2026Review
- Integrated study of rhizosphere microbiome and metabolome profiles across tropical plantations in the Western Ghat regions of Kerala and Tamil Nadu, India.Frontiers in microbiology · 2026Article
- The Evolutionary History and Modern Diversity of Triterpenoid Cyclases.Molecular biology and evolution · 2025Article
- The evolutionary history and modern diversity of triterpenoid cyclases.bioRxiv : the preprint server for biology · 2025Article
- A geranylgeranyl reductase homolog required for cholesterol production in Myxococcota.Journal of bacteriology · 2025Article
- A century of research on the Planctomycetota bacterial phylum, previously known as Planctomycetes.FEMS microbiology reviews · 2025Review
- Elucidation of sterol biosynthesis pathway and its co-regulation with fatty acid biosynthesis in the oleaginous marine protistFrontiers in bioengineering and biotechnology · 2023Article
- The squalene route to C30 carotenoid biosynthesis and the origins of carotenoid biosynthetic pathways.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Reconciling Asgardarchaeota Phylogenetic Proximity to Eukaryotes and Planctomycetes Cellular Features in the Evolution of Life.Molecular biology and evolution · 2021Article
- Analysis of Bacterial Communities on North Sea Macroalgae and Characterization of the Isolated PlanctomycetesMicroorganisms · 2021Article
- The effect of bile acids on the growth and global gene expression profiles in Akkermansia muciniphila.Applied microbiology and biotechnology · 2020Article
- Maioricimonas rarisocia gen. nov., sp. nov., a novel planctomycete isolated from marine sediments close to Mallorca Island.Antonie van Leeuwenhoek · 2020Article
- Origin and Evolution of Polycyclic Triterpene Synthesis.Molecular biology and evolution · 2020Article
- A Fungal Diterpene Synthase Is Responsible for Sterol Biosynthesis for Growth.Frontiers in microbiology · 2020Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Sterols and hopanoids are chemically and structurally related lipids mostly found in eukaryotic and bacterial cell membranes. Few bacterial species have been reported to produce sterols and this anomaly had originally been ascribed to lateral gene transfer (LGT) from eukaryotes. In addition, the functions of sterols in these bacteria are unknown and the functional overlap between sterols and hopanoids is still unclear. Gemmata obscuriglobus is a bacterium from the Planctomycetes phylum that synthesizes sterols, in contrast to its hopanoid-producing relatives. Here we show that sterols are essential for growth of G. obscuriglobus, and that sterol depletion leads to aberrant membrane structures and defects in budding cell division. This report of sterol essentiality in a prokaryotic species advances our understanding of sterol distribution and function, and provides a foundation to pursue fundamental questions in evolutionary cell biology.
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