Evidence map›Paper›PMID 31266890›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Insula serotonin 2A receptor binding and gene expression contribute to serotonin transporter polymorphism anxious phenotype in primates.

Andrea M Santangelo, Steve J Sawiak, Tim Fryer, Young Hong, Yoshiro Shiba, Hannah F Clarke, Patrick J Riss, Valentina Ferrari, Roger Tait, John Suckling and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Resting-State fMRI-Based Screening of Deschloroclozapine in Rhesus Macaques Predicts Dosage-Dependent Behavioral Effects.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Andrea M SantangeloDepartment of Physiology, Development and Neuroscience, University of Cambridge, CB2 3DY Cambridge, United Kingdom; as966@cam.ac.uk.ORCID 0000-0001-7727-2651
Steve J SawiakDepartment of Physiology, Development and Neuroscience, University of Cambridge, CB2 3DY Cambridge, United Kingdom.ORCID 0000-0003-4210-9816
Tim FryerDepartment of Clinical Neuroscience, Wolfson Brain Imaging Centre, University of Cambridge, CB2 0QQ, United Kingdom.
Young HongDepartment of Clinical Neuroscience, Wolfson Brain Imaging Centre, University of Cambridge, CB2 0QQ, United Kingdom.
Yoshiro ShibaDepartment of Physiology, Development and Neuroscience, University of Cambridge, CB2 3DY Cambridge, United Kingdom.
Hannah F ClarkeDepartment of Physiology, Development and Neuroscience, University of Cambridge, CB2 3DY Cambridge, United Kingdom.ORCID 0000-0002-1289-8917
Patrick J RissDepartment of Clinical Neuroscience, Wolfson Brain Imaging Centre, University of Cambridge, CB2 0QQ, United Kingdom.
Valentina FerrariDepartment of Clinical Neuroscience, Wolfson Brain Imaging Centre, University of Cambridge, CB2 0QQ, United Kingdom.
Roger TaitBehavioural and Clinical Neuroscience Institute, University of Cambridge, CB2 3EB Cambridge, United Kingdom.
John SucklingDepartment of Clinical Neuroscience, Wolfson Brain Imaging Centre, University of Cambridge, CB2 0QQ, United Kingdom.
Franklin I AigbirhioDepartment of Clinical Neuroscience, Wolfson Brain Imaging Centre, University of Cambridge, CB2 0QQ, United Kingdom.
Angela C RobertsDepartment of Physiology, Development and Neuroscience, University of Cambridge, CB2 3DY Cambridge, United Kingdom.
University of Cambridge · GB

Funding

Medical Research Council G0900903Medical Research Council G0901884Medical Research Council G1100307Medical Research Council MR/M023990/1Wellcome Trust
6 · The paper itself

Abstract

Genetic variation in the serotonin transporter gene (

Indexed as

AnimalsAnxietyBehavior, AnimalCallithrixCerebral CortexFemaleFluorobenzenesGenotypeHumansInjections, IntramuscularMaleModels, AnimalPiperidinesPolymorphism, GeneticPromoter Regions, GeneticReceptor, Serotonin, 5-HT2AFluorobenzenesPiperidinesReceptor, Serotonin, 5-HT2ARNASerotonin 5-HT2 Receptor AntagonistsSerotonin Plasma Membrane Transport Proteinsvolinanserinanxietyinsula cortexserotonin 2A receptorserotonin transporter polymorphism

Identifiers

PMID31266890
PMCPMC6642374
OpenAlexW2949778090

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.