Evidence map›Paper›PMID 31266863›Full record

ArticlemBio2019

Zika Virus-Immune Plasmas from Symptomatic and Asymptomatic Individuals Enhance Zika Pathogenesis in Adult and Pregnant Mice.

Byoung-Shik Shim, Young-Chan Kwon, Michael J Ricciardi, Mars Stone, Yuka Otsuka, Fatma Berri, Jaclyn M Kwal, Diogo M Magnani, Cody B Jackson, Audrey S Richard and 6 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
5.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

  1. Pooled it
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  5. Bioprofiling and vaccine development for Zika virus.Science China. Life sciences · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Byoung-Shik Shim *Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, Florida, USA.
Young-Chan Kwon *Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, Florida, USA.
Michael J RicciardiDepartment of Pathology, University of Miami Leonard M. Miller School of Medicine, Miami, Florida, USA.
Mars StoneViral Reference Laboratory and Repository Core, Blood Systems Research Institute, San Francisco, California, USA.ORCID 0000-0001-5619-2767
Yuka OtsukaDepartment of Immunology and Microbiology, The Scripps Research Institute, Jupiter, Florida, USA.
Fatma BerriDepartment of Immunology and Microbiology, The Scripps Research Institute, Jupiter, Florida, USA.
Jaclyn M KwalDepartment of Obstetrics and Gynecology, University of Miami Leonard M. Miller School of Medicine, Miami, Florida, USA.
Diogo M MagnaniDepartment of Pathology, University of Miami Leonard M. Miller School of Medicine, Miami, Florida, USA.
Cody B JacksonDepartment of Immunology and Microbiology, The Scripps Research Institute, Jupiter, Florida, USA.
Audrey S RichardDepartment of Immunology and Microbiology, The Scripps Research Institute, Jupiter, Florida, USA.
Philip NorrisViral Reference Laboratory and Repository Core, Blood Systems Research Institute, San Francisco, California, USA.ORCID 0000-0003-0526-2088
Michael BuschViral Reference Laboratory and Repository Core, Blood Systems Research Institute, San Francisco, California, USA.
Christine L CurryDepartment of Obstetrics and Gynecology, University of Miami Leonard M. Miller School of Medicine, Miami, Florida, USA.
Michael FarzanDepartment of Immunology and Microbiology, The Scripps Research Institute, Jupiter, Florida, USA.
David WatkinsDepartment of Pathology, University of Miami Leonard M. Miller School of Medicine, Miami, Florida, USA.
Hyeryun ChoeDepartment of Immunology and Microbiology, The Scripps Research Institute, Jupiter, Florida, USA hchoe@scripps.edu.
Scripps Research Institute · USUniversity of Miami · USUniversity of California, San Francisco · USBlood Systems Research Institute · US

Funding

Phosphatidylserine Receptors in Flavivirus InfectionR01AI110692 · NIAID · SCRIPPS FLORIDA · PI CHOE, HYERYUN · 2014 to 2018
$2.4M
Causes and implications of differential AXL use by ZIKV and WNVR56AI132515 · NIAID · SCRIPPS FLORIDA · PI CHOE, HYERYUN · 2017 to 2017
$527k
NHLBI NIH HHS HHSN268201100001INIAID NIH HHS R01 AI110692NIAID NIH HHS R56 AI132515WHI NIH HHS HHSN268201100001C
6 · The paper itself

Abstract

Preexisting immunity against dengue virus or West Nile virus was previously reported to mediate antibody-dependent enhancement (ADE) of Zika virus (ZIKV) infection in a mouse model. We show here that ZIKV-immune plasma samples from both symptomatic and asymptomatic individuals mediated ZIKV ADE of infection

Indexed as

Antibody-Dependent EnhancementAdultAnimalsAntibodies, ViralDisease Models, AnimalHumansImmune SeraMiceModels, TheoreticalViral LoadZika VirusZika Virus InfectionAntibodies, ViralImmune Seraantibody-dependent enhancementcongenital diseasehomotypicmicrocephalypregnancyvaccineviral pathogenesisZika virus

Identifiers

PMID31266863
PMCPMC6606798
OpenAlexW2954941987

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.