ArticlemBio2019
Toxoplasma gondii Parasitophorous Vacuole Membrane-Associated Dense Granule Proteins Orchestrate Chronic Infection and GRA12 Underpins Resistance to Host Gamma Interferon.
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In one paragraph
Article in mBio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
8.0field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
56 citing papers in PubMed, 88 citations in OpenAlex.
- Immunogenicity of a Recombinant Multi-Epitope Vaccine Incorporating GRA14, SAG1, and GRA1 Antigens ofVaccines · 2026Article
- First Direct Evidence for a Structurally Stable Adhesion Between the Perialgal Vacuole Membrane and Host Mitochondria in theBiomolecules · 2026Article
- Development and evaluation of recombinant dense granule 14 for serological diagnosis of Toxoplasma gondii infection in domestic cats.Scientific reports · 2026Article
- Toxoplasma gondii GRA3 activates interferon-stimulated genes and STAT6 by the cGAS-STING pathway to promote parasite proliferation.PLoS neglected tropical diseases · 2026Article
- Dense granule proteins: key mediators ofFrontiers in medicine · 2026Review
- Immunogenicity and Protective Efficacy of a RecombinantVaccines · 2025Article
- Protective Efficacy Induced by Virus-like Particles Expressing Dense Granule Protein 5 ofVaccines · 2025Article
- From pathogen to cure: exploring the antitumor potential of Toxoplasma gondii.Infectious agents and cancer · 2025Review
- Anti-Toxoplasma gondii efficacy of beta, beta-dimethylacrylshikonin and isobutyrylshikonin in vitro and in vivo.Parasites & vectors · 2025Article
- GRA12 is a common virulence factor across Toxoplasma gondii strains and mouse subspecies.Nature communications · 2025Article
- Study of dense granule proteins inFrontiers in immunology · 2025Article
- Paracrine rescue of MYR1-deficienteLife · 2024Article
- Cloning, expression, and purification of an α-carbonic anhydrase fromJournal of enzyme inhibition and medicinal chemistry · 2024Article
- Functional dissection of prenyltransferases reveals roles in endocytosis and secretory vacuolar sorting in type 2-ME49 strain ofVirulence · 2024Article
- Article
- CRISPR-based functional profiling of the Toxoplasma gondii genome during acute murine infection.Nature microbiology · 2024Article
- Article
- Genetic diversity of Toxoplasma gondii in South America: occurrence, immunity, and fate of infection.Parasites & vectors · 2023Review
- ThemSphere · 2023Article
- A heterotrimeric complex of Toxoplasma proteins promotes parasite survival in interferon gamma-stimulated human cells.PLoS biology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 5 institutions in 2 countries.
Barbara A Fox *Department of Microbiology and Immunology, The Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA.
Rebekah B Guevara *Department of Microbiology and Immunology, The Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA.
Leah M Rommereim *Department of Microbiology and Immunology, The Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA.
Alejandra FallaDepartment of Microbiology and Immunology, The Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA.
Valeria BelliniLaboratoire Techniques de l'Ingénierie Médicale et de la Complexité-Informatique, Mathématiques, Applications, Grenoble (TIMC-IMAG), Université Grenoble Alpes, Grenoble, France.
Graciane PètreLaboratoire Techniques de l'Ingénierie Médicale et de la Complexité-Informatique, Mathématiques, Applications, Grenoble (TIMC-IMAG), Université Grenoble Alpes, Grenoble, France.
Camille RakLaboratoire Techniques de l'Ingénierie Médicale et de la Complexité-Informatique, Mathématiques, Applications, Grenoble (TIMC-IMAG), Université Grenoble Alpes, Grenoble, France.
Viviana CantillanaDepartment of Medicine, Duke University Medical Center, Durham, North Carolina, USA.
Jean-François DubremetzUniversité Montpellier 2, Montpellier, France.
Marie-France Cesbron-DelauwLaboratoire Techniques de l'Ingénierie Médicale et de la Complexité-Informatique, Mathématiques, Applications, Grenoble (TIMC-IMAG), Université Grenoble Alpes, Grenoble, France.
Gregory A TaylorDepartment of Medicine, Duke University Medical Center, Durham, North Carolina, USA.
Corinne MercierLaboratoire Techniques de l'Ingénierie Médicale et de la Complexité-Informatique, Mathématiques, Applications, Grenoble (TIMC-IMAG), Université Grenoble Alpes, Grenoble, France.
David J BzikDepartment of Microbiology and Immunology, The Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA david.j.bzik@dartmouth.edu.
Centre National de la Recherche Scientifique · FRDartmouth College · USDuke Medical Center · USDuke University · USUniversité de Montpellier · FR
Funding
IMMUNOBIOLOGY OF MYELOID AND LYMPHOID CELLST32AI007363 · NIAID · DARTMOUTH COLLEGE · PI Claudia V Jakubzick · 1990 to 2026
$9.5MHOST-MICROBE INTERACTIONST32AI007519 · NIAID · DARTMOUTH COLLEGE · PI DEBORAH A HOGAN · 1997 to 2026
$5.9MT GONDII--PYRIMIDINE SYNTHESIS AS A CHEMOTHERAPY TARGETR01AI041930 · NIAID · DARTMOUTH COLLEGE · PI BZIK, DAVID J · 1997 to 2013
$4.2MIntravacuolar network dense granule protein biology in chronic Toxoplasma infectionR21AI152687 · NIAID · DARTMOUTH COLLEGE · PI BZIK, DAVID J · 2020 to 2021
$451kGenetic models for latent Toxoplasma gondii infectionR21AI137118 · NIAID · DARTMOUTH COLLEGE · PI BZIK, DAVID J · 2018 to 2019
$446kDense granule protein virulence factors in Toxoplasma gondii infectionR21AI108489 · NIAID · DARTMOUTH COLLEGE · PI BZIK, DAVID J · 2014 to 2015
$446kNovel rhoptry protein function in chronic toxoplasma infectionR21AI129869 · NIAID · DARTMOUTH COLLEGE · PI BZIK, DAVID J · 2017 to 2018
$446kNovel virulence function in Toxoplasma chronic infectionR21AI131630 · NIAID · DARTMOUTH COLLEGE · PI BZIK, DAVID J · 2018 to 2019
$446kParasite secreted proteins control host response to Toxoplasma gondii infectionR21AI104514 · NIAID · DARTMOUTH COLLEGE · PI BZIK, DAVID J · 2013 to 2014
$445kRegulation of T cell metabolism and function by IRGM proteinsR21AI135398 · NIAID · DUKE UNIVERSITY · PI MACIVER, NANCIE, TAYLOR, GREGORY A · 2019 to 2020
$442kRegulated virulence and cyst maturation in Toxoplasma gondiiR21AI075931 · NIAID · DARTMOUTH COLLEGE · PI BZIK, DAVID J · 2008 to 2009
$440kGenetic models for post-genome functional analysis of Toxoplasma gondiiR21AI084570 · NIAID · DARTMOUTH COLLEGE · PI BZIK, DAVID J · 2009 to 2010
$435kBLRD VA I01 BX002369NIAID NIH HHS R01 AI041930NIAID NIH HHS R21 AI075931NIAID NIH HHS R21 AI084570NIAID NIH HHS R21 AI104514NIAID NIH HHS R21 AI105563NIAID NIH HHS R21 AI108489NIAID NIH HHS R21 AI129869NIAID NIH HHS R21 AI131630NIAID NIH HHS R21 AI135398NIAID NIH HHS R21 AI137118NIAID NIH HHS R21 AI152687NIAID NIH HHS T32 AI007363NIAID NIH HHS T32 AI007519
Abstract
PubMed holds no abstract for this paper.
Indexed as
Host-Pathogen InteractionsImmune EvasionAnimalsCells, CulturedCell SurvivalDisease Models, AnimalFemaleGene DeletionInterferon-gammaIntracellular MembranesMice, Inbred C57BLMice, KnockoutModels, TheoreticalProtozoan ProteinsSurvival AnalysisToxoplasmaInterferon-gammaProtozoan ProteinsVirulence Factorschronic infectiondense granuleinnate immunitymembrane proteinsToxoplasma gondiivirulence factors
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.