Evidence map›Paper›PMID 31266826›Full record

Trial reportCancer prevention research (Philadelphia, Pa.)2019

Proteomic Analysis of Plasma Reveals Fat Mass Influences Cancer-Related Pathways in Healthy Humans Fed Controlled Diets Differing in Glycemic Load.

Carly B Garrison, Yuzheng Zhang, Sandi L Navarro, Timothy W Randolph, Meredith A J Hullar, Mario Kratz, Marian L Neuhouser, Daniel Raftery, Paul D Lampe, Johanna W Lampe

Open access · bronzeAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Cancer prevention research (Philadelphia, Pa.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Carly B GarrisonDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Yuzheng ZhangDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Sandi L NavarroDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.ORCID 0000-0002-4260-2486
Timothy W RandolphDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Meredith A J HullarDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Mario KratzDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.ORCID 0000-0003-2660-8033
Marian L NeuhouserDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Daniel RafteryDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.ORCID 0000-0003-2467-8118
Paul D LampeDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.ORCID 0000-0002-1399-2761
Johanna W LampeDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington. jlampe@fredhutch.org.ORCID 0000-0003-2717-3780
Fred Hutch Cancer Center · USUniversity of Washington · US

Funding

Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4M
Preventing obesity in low income working adultsU54CA116847 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI MCTIERNAN, ANNE M. · 2005 to 2010
$12.6M
Human and Bacterial Molecular Pathways in Cancer Risk: Modulation by DietR01CA192222 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI LAMPE, JOHANNA W · 2016 to 2019
$2.9M
NCI NIH HHS P30 CA015704NCI NIH HHS R01 CA192222NCI NIH HHS U54 CA116847
6 · The paper itself

Abstract

Increased adiposity and diets high in glycemic load (GL) are associated with increased risk of many chronic diseases including cancer. Using plasma from 80 healthy individuals [40 men/40 women, 29 with DXA-derived low fat mass (FM) and 51 with high FM] in a randomized cross-over-controlled feeding trial and arrays populated with 3,504 antibodies, we measured plasma proteins collected at baseline and end of each of two 28-day controlled diets: a low GL diet high in whole grains, legumes, fruits, and vegetables (WG) and a high GL diet high in refined grains and added sugars (RG). Following univariate testing for proteins differing by diet, we evaluated pathway-level involvement. Among all 80 participants, 172 proteins were identified as differing between diets. Stratifying participants by high and low FM identified 221 and 266 proteins, respectively, as differing between diets (unadjusted

Indexed as

DietAdipose TissueAdiposityAdolescentAdultBlood Chemical AnalysisBlood ProteinsCross-Over StudiesFeeding BehaviorFemaleGlycemic LoadHumansMaleMiddle AgedNeoplasmsOrgan SizeBlood ProteinsProteome

Identifiers

PMID31266826
PMCPMC6726515
OpenAlexW2954370507

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.