Evidence map›Paper›PMID 31266816›Full record

ArticleMolecular cancer research : MCR2019

A Novel FGFR3 Splice Variant Preferentially Expressed in African American Prostate Cancer Drives Aggressive Phenotypes and Docetaxel Resistance.

Jacqueline Olender, Bi-Dar Wang, Travers Ching, Lana X Garmire, Kaitlin Garofano, Youngmi Ji, Tessa Knox, Patricia Latham, Kenneth Nguyen, Johng Rhim and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Molecular cancer research : MCR, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 15 citations in OpenAlex.

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  6. Targeting RNA splicing modulation: new perspectives for anticancer strategy?Journal of experimental & clinical cancer research : CR · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Jacqueline OlenderDepartment of Pharmacology and Physiology, The George Washington University School of Medicine and Health Sciences, GW Cancer Center, Washington, D. C.
Bi-Dar WangDepartment of Pharmaceutical Sciences, School of Pharmacy and Health Professions, University of Maryland Eastern Shore, Princess Anne, Maryland.ORCID 0000-0002-2530-7020
Travers ChingCancer Epidemiology Program, University of Hawaii, Honolulu, Hawaii.ORCID 0000-0002-5577-3516
Lana X GarmireDepartment of Computational Medicine and Bioinformatics, School of Medicine, University of Michigan, Ann Arbor, Michigan.ORCID 0000-0002-4654-2126
Kaitlin GarofanoDepartment of Pharmacology and Physiology, The George Washington University School of Medicine and Health Sciences, GW Cancer Center, Washington, D. C.ORCID 0000-0003-4082-5288
Youngmi JiAdeno-Associated Virus Biology Section, National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland.
Tessa KnoxDepartment of Pharmacology and Physiology, The George Washington University School of Medicine and Health Sciences, GW Cancer Center, Washington, D. C.
Patricia LathamDepartment of Pathology, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia.ORCID 0000-0003-2782-9444
Kenneth NguyenDepartment of Pharmacology and Physiology, The George Washington University School of Medicine and Health Sciences, GW Cancer Center, Washington, D. C.
Johng RhimCenter for Prostate Disease Research, Department of Surgery, Uniformed Services University of Health Sciences, Bethesda, Maryland.
Norman H LeeDepartment of Pharmacology and Physiology, The George Washington University School of Medicine and Health Sciences, GW Cancer Center, Washington, D. C. nhlee@gwu.edu.
George Washington University · USNational Institute of Dental and Craniofacial Research · USUniformed Services University of the Health Sciences · USUniversity of Hawaii System · USUniversity of Maryland Eastern Shore · USUniversity of Michigan · US

Funding

Transgenic Mouse, ICSI and IVF CoreP20GM103457 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI URSCHITZ, JOHANN · 2012 to 2018
$12.9M
An Integrative Omics Approach to Identify Biomarkers Related to Preeclampsia and Breast Cancer RisksR01HD084633 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GARMIRE, LANA X · 2016 to 2020
$3.0M
Consequences and mechanism of aberrant splicing in African American prostate cancer disparitiesR01CA204806 · NCI · GEORGE WASHINGTON UNIVERSITY · PI GARCIA-BLANCO, MARIANO A., LEE, NORMAN H · 2017 to 2021
$1.8M
Aberrant Splice Variants as Potential Precision Biomarkers for Aggressive Prostate Cancers in African American PatientsSC1GM127256 · NIGMS · UNIVERSITY OF MARYLAND EASTERN SHORE · PI WANG, BI-DAR · 2019 to 2022
$1.6M
An Integrative Bioinformatics Approach to Study Single Cancer Cell HeterogeneityK01ES025434 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GARMIRE, LANA X · 2014 to 2018
$905k
NCI NIH HHS R01 CA204806NICHD NIH HHS R01 HD084633NIEHS NIH HHS K01 ES025434NIGMS NIH HHS P20 GM103457NIGMS NIH HHS SC1 GM127256
6 · The paper itself

Abstract

Alternative splicing (AS) has been shown to participate in prostate cancer development and progression; however, a link between AS and prostate cancer health disparities has been largely unexplored. Here we report on the cloning of a novel splice variant of

Indexed as

Alternative SplicingAnimalsBlack or African AmericanCell Line, TumorDocetaxelDrug Resistance, NeoplasmHumansMalePC-3 CellsPhenotypeProstatic NeoplasmsRabbitsReceptor, Fibroblast Growth Factor, Type 3RNA SplicingSignal TransductionSurvival AnalysisDocetaxelFGFR3 protein, humanReceptor, Fibroblast Growth Factor, Type 3

Identifiers

PMID31266816
PMCPMC6886680
OpenAlexW2955981332

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.