Evidence map›Paper›PMID 31266784›Full record

ArticleCancer immunology research2019

An Anticancer Drug Cocktail of Three Kinase Inhibitors Improved Response to a Dendritic Cell-Based Cancer Vaccine.

Jitao Guo, Elena Muse, Allison J Christians, Steven J Swanson, Eduardo Davila

Abstract read
In one paragraph

Article in Cancer immunology research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. DNA sensing of dendritic cells in cancer immunotherapy.Frontiers in molecular biosciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Jitao GuoDivision of Medical Oncology, Department of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, Colorado.
Elena MuseDivision of Medical Oncology, Department of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, Colorado.
Allison J ChristiansDivision of Medical Oncology, Department of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, Colorado.ORCID 0000-0001-5881-3184
Steven J SwansonImmunoCellular Therapeutics, Ltd., Westlake Village, California.
Eduardo DavilaDivision of Medical Oncology, Department of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, Colorado. eduardo.davila@ucdenver.edu.
University of Colorado Anschutz Medical Campus · USImmunoCellular Therapeutics (United States) · USUniversity of Colorado Cancer Center · US

Funding

University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0M
UNIVERSITY OF MARYLAND GREENEBAUM CANCER CENTERSUPPORT GRANTP30CA134274 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI FEYRUZ VIRGILIA RASSOOL · 2008 to 2026
$51.0M
Augmenting T cell activity to weak tumor antigens and reversing myeloid cell-mediated T cell inhibitionR01CA207913 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI DAVILA, EDUARDO V · 2017 to 2021
$1.9M
IL-1 Receptor-Associated Kinase as a Cancer Therapeutic TargetI01BX002142 · VA · VA EASTERN COLORADO HEALTH CARE SYSTEM · PI DAVILA, EDUARDO V · 2015 to 2019
–
BLRD VA I01 BX002142BLRD VA I01 BX004935NCI NIH HHS P30 CA046934NCI NIH HHS P30 CA134274NCI NIH HHS R01 CA207913
6 · The paper itself

Abstract

Monocyte-derived dendritic cell (moDC)-based cancer therapies intended to elicit antitumor T-cell responses have limited efficacy in most clinical trials. However, potent and sustained antitumor activity in a limited number of patients highlights the therapeutic potential of moDCs.

Indexed as

AnimalsAntineoplastic Combined Chemotherapy ProtocolsCancer VaccinesCell CommunicationChromonesDendritic CellsHeterocyclic Compounds, 3-RingHumansLymphocyte ActivationMaleMiceMorpholinesNeoplasmsProtein Kinase InhibitorsT-Lymphocyte Subsets8-dibenzothiophen-4-yl-2-morpholin-4-yl-chromen-4-oneCancer VaccinesChromonesHeterocyclic Compounds, 3-RingMK 2206MorpholinesProtein Kinase Inhibitors

Identifiers

PMID31266784
PMCPMC6726569
OpenAlexW2954513055

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.