ArticleCancer discovery2019
Innate αβ T Cells Mediate Antitumor Immunity by Orchestrating Immunogenic Macrophage Programming.
Open access · bronzeAbstract read
In one paragraph
Article in Cancer discovery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 24 citations in OpenAlex.
- IFITM1 enhances anti-tumor function of unconventional TCRαβ double negative T cells by upregulating mitophagy.Science China. Life sciences · 2026Article
- SLAMF7 promotes TCRαβJournal of experimental & clinical cancer research : CR · 2025Article
- LAG3 as a marker of immune activation in esophageal squamous carcinoma treated with concurrent chemoradiotherapy.Cancer immunology, immunotherapy : CII · 2025Article
- CSTF2-impeded innate αβ T cell infiltration and activation exacerbate immune evasion of pancreatic cancer.Cell death and differentiation · 2025Article
- Genetics and biology of pancreatic ductal adenocarcinoma.Genes & development · 2025Review
- Orchestration of Tumor-Associated Macrophages in the Tumor Cell-Macrophage-CD8International journal of biological sciences · 2025Review
- C-C chemokine receptor 5 is essential for conventional NK cell trafficking and liver injury in a murine hepatitis virus-induced fulminant hepatic failure model.Journal of translational medicine · 2023Article
- scRNA-Seq and imaging mass cytometry analyses unveil iNKT cells-mediated anti-tumor immunity in pancreatic cancer liver metastasis.Cancer letters · 2023Article
- Targeting T cell checkpoints 41BB and LAG3 and myeloid cell CXCR1/CXCR2 results in antitumor immunity and durable response in pancreatic cancer.Nature cancer · 2023Article
- CCR2/CCR5 inhibitor permits the radiation-induced effector T cell infiltration in pancreatic adenocarcinoma.The Journal of experimental medicine · 2022Article
- N7-Methylguanosine-Related lncRNAs: Integrated Analysis Associated With Prognosis and Progression in Clear Cell Renal Cell Carcinoma.Frontiers in genetics · 2022Article
- Characterization of the tumor immune microenvironment of sinonasal squamous-cell carcinoma.International forum of allergy & rhinology · 2022Article
- Pancreatic Cancer Immuno-oncology in the Era of Precision Medicine.Indian journal of surgical oncology · 2021Review
- Leronlimab, a humanized monoclonal antibody to CCR5, blocks breast cancer cellular metastasis and enhances cell death induced by DNA damaging chemotherapy.Breast cancer research : BCR · 2021Article
- Regulation and modulation of antitumor immunity in pancreatic cancer.Nature immunology · 2020Review
- Pancreatic Cancer and Its Microenvironment-Recent Advances and Current Controversies.International journal of molecular sciences · 2020Review
- Targeting the interleukin-17 immune axis for cancer immunotherapy.The Journal of experimental medicine · 2020Review
- 3D approaches to model the tumor microenvironment of pancreatic cancer.Theranostics · 2020Review
Corrections and comments
- Commented on by
Authors and funding
37 authors at 2 institutions in 1 country.
Mautin HundeyinS.A. Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York.
Emma KurzS.A. Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York.
Ankita MishraS.A. Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York.
Juan Andres Kochen RossiS.A. Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York.
Shannon M LiudahlDepartment of Cell, Developmental and Cancer Biology, Oregon Health and Science University, Portland, Oregon.
Kenna R LeisDepartment of Cell, Developmental and Cancer Biology, Oregon Health and Science University, Portland, Oregon.
Harshita MehrotraS.A. Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York.
Mirhee KimS.A. Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York.
Luisana E TorresS.A. Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York.
Adesola OgunsakinS.A. Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York.
Jason LinkDepartment of Molecular and Medical Genetics, Oregon Health and Science University, Portland, Oregon.
Rosalie C SearsDepartment of Molecular and Medical Genetics, Oregon Health and Science University, Portland, Oregon.
Shamilene SivagnanamComputational Biology Program, Oregon Health and Science University, Portland, Oregon.
Jeremy GoecksKnight Cancer Institute, Oregon Health and Science University, Portland, Oregon.
K M Sadeq IslamS.A. Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York.
Igor DolgalevDepartment of Pathology, New York University School of Medicine, New York, New York.
Shivraj SavadkarS.A. Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York.
Wei WangS.A. Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York.
Berk AykutS.A. Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York.
Joshua LeinwandS.A. Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York.
Brian DiskinS.A. Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York.
Salma AdamS.A. Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York.
Muhammad IsrarS.A. Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York.
Maeliss GelasS.A. Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York.
Justin LishS.A. Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York.
Kathryn ChinS.A. Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York.
Mohammad Saad FarooqS.A. Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York.
Benjamin WadowskiS.A. Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York.
Jingjing WuS.A. Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York.
Suhagi ShahDepartment of Medicine, New York University School of Medicine, New York, New York.
Dennis O AdeegbeDepartment of Medicine, New York University School of Medicine, New York, New York.
Smruti PushalkarDepartment of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, New York.
Varshini VasudevarajaDepartment of Pathology, New York University School of Medicine, New York, New York.
Deepak SaxenaDepartment of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, New York.
Kwok-Kin WongDepartment of Medicine, New York University School of Medicine, New York, New York.
Lisa M CoussensDepartment of Cell, Developmental and Cancer Biology, Oregon Health and Science University, Portland, Oregon.
George MillerS.A. Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York. george.miller@nyumc.org.
New York University · USOregon Health & Science University · US
Funding
Understanding the origins of rapid recurrence of pancreatic cancer after resectionP30CA069533 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Luiz Eduardo Bertassoni · 1997 to 2026
$60.5MHydroxylation regulation of c-MycR01CA186241 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Mu-Shui Dai, ROSALIE C SEARS · 2015 to 2026
$4.2MResearch Training for Physician-Scientists in Gastrointestinal OncologyT32CA193111 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BAR-SAGI, DAFNA, WOLFGANG, CHRISTOPHER L. · 2015 to 2024
$2.7MDectin-1 signaling drives pancreatic oncogenesis by inducing macrophage-mediated adaptive immune suppressionR01CA215471 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BAR-SAGI, DAFNA, WONG, KWOK KIN · 2018 to 2022
$2.3MToll-like Receptor Regulation of Pancreatic TumorigenesisR01CA168611 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI COHEN, DEIRDRE, MILLER, GEORGE · 2013 to 2019
$2.1MDectin-1 Regulates Chronic Liver Fibro-inflammatory DiseaseR01DK106025 · NIDDK · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MILLER, GEORGE · 2016 to 2018
$1.3MNCI NIH HHS P30 CA069533NCI NIH HHS R01 CA168611NCI NIH HHS R01 CA186241NCI NIH HHS R01 CA215471NCI NIH HHS T32 CA193111NIDDK NIH HHS R01 DK106025
Abstract
Unconventional T-lymphocyte populations are emerging as important regulators of tumor immunity. Despite this, the role of TCRαβ
Indexed as
AnimalsCarcinoma, Pancreatic DuctalCell Line, TumorFemaleHumansImmunity, InnateImmunotherapy, AdoptiveMacrophagesMaleMiceMice, Inbred C57BLNeoplasm TransplantationPancreatic NeoplasmsReceptors, Antigen, T-Cell, alpha-betaT-LymphocytesTumor MicroenvironmentReceptors, Antigen, T-Cell, alpha-beta
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.