ArticleeLife2019
Ancient origins of arthropod moulting pathway components.
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 48 citations in OpenAlex.
- Evolutionary dynamics of the arthropod molting machinery.Molecular biology and evolution · 2026Review
- Investigating Low-Temperature Stress Responses in Crustacea Aquatic Species Through Comparative Transcriptomics.Evolutionary applications · 2026Article
- ETH and Burs-α are necessary for the normal molting inFrontiers in insect science · 2026Article
- Article
- Characterization and Analysis of the Functional Differences of the Two Eclosion Hormones in Regulating Molting in the White ShrimpInternational journal of molecular sciences · 2024Article
- Novel regulation pathway of eclosion hormones in Tribolium castaneum by distinct transcription factors through the initiation of 20-hydroxyecdysone.The Journal of biological chemistry · 2024Article
- The Caenorhabditis elegans cuticle and precuticle: a model for studying dynamic apical extracellular matrices in vivo.Genetics · 2024Review
- Article
- Large-scale deorphanization ofeLife · 2024Article
- Neuromodulation and the toolkit for behavioural evolution: can ecdysis shed light on an old problem?The FEBS journal · 2024Review
- Storage cell proliferation during somatic growth establishes that tardigrades are not eutelic organisms.Biology open · 2024Article
- Ontogeny of the Cytochrome P450 Superfamily in the Ornate Spiny Lobster (International journal of molecular sciences · 2024Article
- Identification and characterization of ecdysis-related neuropeptides in the lone star tickFrontiers in endocrinology · 2023Article
- Insect PRXamides: Evolutionary Divergence, Novelty, and Loss in a Conserved Neuropeptide System.Journal of insect science (Online) · 2023Article
- Premetazoan Origin of Neuropeptide Signaling.Molecular biology and evolution · 2022Article
- Transcriptome Profiling of the Pacific OysterMarine drugs · 2021Article
- The chemical brain hypothesis for the origin of nervous systems.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- Signaling Pathways That Regulate the Crustacean Molting Gland.Frontiers in endocrinology · 2021Review
- Two Splice Isoforms ofFrontiers in physiology · 2020Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
Abstract
Ecdysis (moulting) is the defining character of Ecdysoza (arthropods, nematodes and related phyla). Despite superficial similarities, the signalling cascade underlying moulting differs between Panarthropoda and the remaining ecdysozoans. Here, we reconstruct the evolution of major components of the ecdysis pathway. Its key elements evolved much earlier than previously thought and are present in non-moulting lophotrochozoans and deuterostomes. Eclosion hormone (EH) and bursicon originated prior to the cnidarian-bilaterian split, whereas ecdysis-triggering hormone (ETH) and crustacean cardioactive peptide (CCAP) evolved in the bilaterian last common ancestor (LCA). Identification of EH, CCAP and bursicon in Onychophora and EH, ETH and CCAP in Tardigrada suggests that the pathway was present in the panarthropod LCA. Trunk, an ancient extracellular signalling molecule and a well-established paralog of the insect peptide prothoracicotropic hormone (PTTH), is present in the non-bilaterian ctenophore
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.