ArticleParasites & vectors2019
Killer yeasts exert anti-plasmodial activities against the malaria parasite Plasmodium berghei in the vector mosquito Anopheles stephensi and in mice.
Article in Parasites & vectors, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Fungal microbiota diversity inWellcome open research · 2026Pooled it
- Unlocking new frontiers in vector control strategies using Aedes aegypti microbiota.Parasites & vectors · 2026Review
- Reinventing malaria control: hierarchical intervention strategies for African settings based on the microbiota-barrier-innate immunity axis.Frontiers in immunology · 2026Review
- Environmental yeasts differentially impact the development and oviposition behavior of the Asian tiger mosquito Aedes albopictus.Microbiome · 2025Article
- A novel inhibitory strategy ofFuture microbiology · 2025Article
- Molecular Basis of Yeasts Antimicrobial Activity-Developing Innovative Strategies for Biomedicine and Biocontrol.Current issues in molecular biology · 2024Review
- Combination of computational techniques and RNAi reveal targets in Anopheles gambiae for malaria vector control.PloS one · 2024Article
- Impact of the microbiome on mosquito-borne diseases.Protein & cell · 2023Review
- Biotechnological Potential of Microorganisms for Mosquito Population Control and Reduction in Vector Competence.Insects · 2023Review
- Tripartite interactions comprising yeast-endobacteria systems in the gut of vector mosquitoes.Frontiers in microbiology · 2023Article
- Targeting malaria parasites inside mosquitoes: ecoevolutionary consequences.Trends in parasitology · 2022Review
- Contemporary exploitation of natural products for arthropod-borne pathogen transmission-blocking interventions.Parasites & vectors · 2022Review
- Overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors.Parasites & vectors · 2022Review
- Formulation and Safety Tests of aToxins · 2021Article
- Review
- Diversity and Functions of Yeast Communities Associated with Insects.Microorganisms · 2021Review
- Fungal deterioration of the bagasse storage from the harvested sugarcane.Biotechnology for biofuels · 2021Article
- The Axenic and Gnotobiotic Mosquito: Emerging Models for Microbiome Host Interactions.Frontiers in microbiology · 2021Review
- Vector-Focused Approaches to Curb Malaria Transmission in the Brazilian Amazon: An Overview of Current and Future Challenges and Strategies.Tropical medicine and infectious disease · 2020Review
- Mosquito Mycobiota: An Overview of Non-Entomopathogenic Fungal Interactions.Pathogens (Basel, Switzerland) · 2020Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundWickerhamomyces anomalus is a yeast associated with different insects including mosquitoes, where it is proposed to be involved in symbiotic relationships with hosts. Different symbiotic strains of W. anomalus display a killer phenotype mediated by protein toxins with broad-spectrum antimicrobial activities. In particular, a killer toxin purified from a W. anomalus strain (WaF17.12), previously isolated from the malaria vector mosquito Anopheles stephensi, has shown strong in vitro anti-plasmodial activity against early sporogonic stages of the murine malaria parasite Plasmodium berghei.
resultsHere, we provide evidence that WaF17.12 cultures, properly stimulated to induce the expression of the killer toxin, can directly affect in vitro P. berghei early sporogonic stages, causing membrane damage and parasite death. Moreover, we demonstrated by in vivo studies that mosquito dietary supplementation with activated WaF17.12 cells interfere with ookinete development in the midgut of An. stephensi. Besides the anti-sporogonic action of WaF17.12, an inhibitory effect of purified WaF17.12-killer toxin was observed on erythrocytic stages of P. berghei, with a consequent reduction of parasitaemia in mice. The preliminary safety tests on murine cell lines showed no side effects.
conclusionsOur findings demonstrate the anti-plasmodial activity of WaF17.12 against different developmental stages of P. berghei. New studies on P. falciparum are needed to evaluate the use of killer yeasts as innovative tools in the symbiotic control of malaria.
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Registered trials
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