Evidence map›Paper›PMID 31266458›Full record

ArticleBMC pediatrics2019

The relationship between payer type and lipid outcomes in response to clinical lifestyle interventions in youth with dyslipidemia.

Jacob C Hartz, Elizabeth Yellen, Annette Baker, Justin Zachariah, Heather Ryan, S Skylar Griggs, Nirav K Desai, Ravi Yanumula, Samuel Vinci, Caroline Brantley and 5 more

Open access · goldAbstract read
In one paragraph

Article in BMC pediatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Jacob C HartzBoston Children's Hospital, 300 Longwood Ave, Boston, MA, 02115, USA. jacob.hartz@cardio.chboston.org.ORCID 0000-0002-6342-4236
Elizabeth YellenBoston Medical Center, 850 Harrison Ave., 6th floor, Boston, MA, 02118, USA.
Annette BakerBoston Children's Hospital, 300 Longwood Ave, Boston, MA, 02115, USA.
Justin ZachariahTexas Children's Hospital Main Campus, 6651 Main Street, Legacy Tower, 21st Floor, Houston, TX, 77030, USA.
Heather RyanSchool of Nursing, University of Massachusetts-Boston, 100 William T. Morrissey Blvd, Boston, MA, 0212, USA.
S Skylar GriggsBoston Children's Hospital, 300 Longwood Ave, Boston, MA, 02115, USA.
Nirav K DesaiBoston Children's Hospital, 300 Longwood Ave, Boston, MA, 02115, USA.
Ravi YanumulaBoston Children's Hospital, 300 Longwood Ave, Boston, MA, 02115, USA.
Samuel VinciSchool of Public Health, University of Washington, 1959 NE Pacific St, Seattle, WA, 98195, USA.
Caroline BrantleyBoston Children's Hospital, 300 Longwood Ave, Boston, MA, 02115, USA.
Jennifer BachmanBoston Children's Hospital, 300 Longwood Ave, Boston, MA, 02115, USA.
Ellen McAuliffeBoston Children's Hospital, 300 Longwood Ave, Boston, MA, 02115, USA.
Kimberlee GauvreauBoston Children's Hospital, 300 Longwood Ave, Boston, MA, 02115, USA.
Michael MendelsonBoston Children's Hospital, 300 Longwood Ave, Boston, MA, 02115, USA.
Sarah de FerrantiBoston Children's Hospital, 300 Longwood Ave, Boston, MA, 02115, USA.
Boston Children's Hospital · USBoston University · USTexas Children's Hospital · USUniversity of Washington · US

Funding

RESEARCH METHODS IN PEDIATRICS HEART DISEASET32HL007572 · NHLBI · CHILDREN'S HOSPITAL BOSTON · PI Sarah D DE FERRANTI, Jane W. Newburger · 1985 to 2026
$13.0M
T32 Institutional Pediatric ResearchT32HD043021 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI Joseph W. St. Geme · 2002 to 2026
$6.4M
Vascular Remodeling in Overweight and Obese AdolescentsK23HL111335 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI ZACHARIAH, JUSTIN P.V. · 2012 to 2017
$708k
Circulating Epigenetic Biomarkers for Personalized Cardiovascular Disease PreventionK99HL136875 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI MENDELSON, MICHAEL MAXWELL · 2017 to 2018
$330k
NHLBI NIH HHS K23 HL111335NHLBI NIH HHS K99 HL136875NHLBI NIH HHS T32 HD043021NHLBI NIH HHS T32 HL007572NICHD NIH HHS T32 HD043021
6 · The paper itself

Abstract

backgroundPayer-type (government-sponsored health coverage versus private health insurance) has been shown to influence a variety of cardiovascular disease outcomes in adults. However, it is unclear if the payer-type impacts the response to a lifestyle intervention in children with dyslipidemia.

methodsWe analyzed data prospectively collected from patients under the age of 25 years who were referred to a large regional preventive cardiology clinic from 2010 to 2016 in Massachusetts. We compared baseline high density lipoprotein cholesterol (HDL-C), triglycerides (TG), non-HDL-C, and low density lipoprotein cholesterol (LDL-C) by payer-type. Further, we analyzed the change in lipid values in response to a clinic-based multidisciplinary intervention over a nearly six-year period by payer-type with multi-variable adjusted linear regression models. We also tested for effect modifications by age, sex, race, and body mass index (BMI) category.

resultsOf the 1739 eligible patients (mean age 13 years, 52% female, 60% overweight and obese, 59% White), we found that patients with government-sponsored coverage (n = 354, 20%) presented to referral lipid clinic with lower HDL-C (- 3.5 mg/dL [1.0], p < 0.001) and higher natural log-transformed TG (+ 0.14 [0.04], p < 0.001) as compared to those with private insurance; however, the association was attenuated to the null after additionally adjusting for BMI category (- 1.1 [0.9], p = 0.13, and + 0.05 [0.04], p = 0.2 for HDL-C and natural log-transformed TG, respectively). We found no difference in baseline LDL-C between payer-types (+ 3.4 mg/dL [3.0], p = 0.3). However, longitudinally, we found patients with private insurance and a self-reported race of White to have a clinically meaningful additional improvement in LDL-C, decreasing 12.8 (5.5) mg/dL (p = 0.02) between baseline and first follow-up, as compared to White patients with government-sponsored health coverage, after adjusting for age, sex, time between visits, and baseline LDL-C.

conclusionsOur results suggest that youth with government-sponsored coverage are referred with poorer lipid profiles than those with private insurance, although this is largely explained by higher rates of overweight and obesity in the government-sponsored health coverage group. White patients with private insurance had substantially better improvement in LDL-C longitudinally, suggesting that higher socioeconomic status facilitates improvement in LDL-C, but is less beneficial for HDL-C and triglyceride levels.

Indexed as

Life StyleAdolescentAge FactorsBody Mass IndexChildCholesterol, HDLCholesterol, LDLDyslipidemiasFemaleFinancing, GovernmentHumansInsurance, Health, ReimbursementLipidsMaleMassachusettsPediatric ObesityCholesterol, HDLCholesterol, LDLLipidsTriglyceridesChildren and adolescentsDyslipidemiaHealth insuranceLifestyle interventionsObesity

Identifiers

PMID31266458
PMCPMC6604145
OpenAlexW2955538894

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.