Evidence map›Paper›PMID 31266451›Full record

SynthesisBMC geriatrics2019

Effects of physical activity and exercise on the cognitive function of patients with Alzheimer disease: a meta-analysis.

Rui-Xia Jia, Jing-Hong Liang, Yong Xu, Ying-Quan Wang

Registry-linked trialAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC geriatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07324330 (Slowing Cognitive Decline in Alpha-synucleinopathies by Enhancing Physical Activity), which is not on this map. Cited by 208 papers, 26 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
208citing papers in PubMed, 26 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07324330 narecruitingnot on this mapstarted 2025, after this paper: background citation

Slowing Cognitive Decline in Alpha-synucleinopathies by Enhancing Physical Activity

TypeinterventionalSponsorUniversity Hospital, BonnRan2025 to 2029Enrolled130ConditionsParkinson Disease, Prodromal Stage, Neurodegenerative Diseases, Basal Ganglia DiseasesArmsIncrease of physical activity volume and intensity with the use of a motivational smartphone application
3 · Its place in the literature

Who cites it

208 citing papers in PubMed, 26 syntheses or guidelines pooled it.

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  3. The effect of exercise on cognitive function in breast cancer survivors: systematic review and meta-analysis of randomized controlled trials.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
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148 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rui-Xia JiaDepartment of Social Medicine, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Medical College of Soochow University, No.199 Ren Ai Road, Suzhou, People's Republic of China, 215123.
Jing-Hong LiangDepartment of Social Medicine, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Medical College of Soochow University, No.199 Ren Ai Road, Suzhou, People's Republic of China, 215123.
Yong XuDepartment of Social Medicine, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Medical College of Soochow University, No.199 Ren Ai Road, Suzhou, People's Republic of China, 215123. 838202104@qq.com.
Ying-Quan WangDepartment of Social Medicine, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Medical College of Soochow University, No.199 Ren Ai Road, Suzhou, People's Republic of China, 215123.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlzheimer's disease (AD), as the most common cause of dementia, brings huge economic burden for patients and social health care systems, which motivates researchers to study multiple protective factors, among which physical activity and exercise have been proven to be both effective and economically feasible.

methodsA systematic literature search was performed for eligible studies published up to November 1st 2018 on three international databases (PubMed, Cochrane Library, and Embase) and two Chinese databases (Wanfang Data, China National Knowledge Infrastructure). All analyses were conducted using Stata 14.0. Due to heterogeneity between studies, a random-effects model was used for this meta-analysis. Meta-analysis was used to explore if physical activity and exercise can exert positive effects on cognition of elderly with AD and subgroup analyses were conducted to find out if there are dose-response effects.

resultsA total of 13 randomized controlled trials were included with a sample size of 673 subjects diagnosed with AD. Intervention groups showed a statistically significant improvement in cognition of included subjects measured by the MMSE score (SMD = 1.12 CI:0.66~1.59) compared to the control groups. Subgroup analyses showed different amounts of physical activity and exercise can generate different effects.

conclusionsAs one of few meta-analyses comparing different quantities of physical activity and exercise interventions for AD in details, our study suggests that physical activity and exercise can improve cognition of older adults with AD. While the concomitant effects on cognition functions of high frequency interventions was not greater than that of low frequency interventions, the threshold remains to be settled. However, more RCTs with rigorous study design are needed to support our findings.

Indexed as

AgedAlzheimer DiseaseChinaCognitionCognition DisordersExerciseHumansRandomized Controlled Trials as TopicTreatment OutcomeAlzheimer’s disease, cognitionElderlyExerciseMeta-analysisOlder adultsPhysical activity

Identifiers

PMID31266451
PMCPMC6604129

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.