ArticleBiology letters2019
An optogenetic analogue of second-order reinforcement in Drosophila.
Article in Biology letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed.
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- Skewing information flow through pre- and postsynaptic plasticity in the mushroom bodies ofLearning & memory (Cold Spring Harbor, N.Y.) · 2024Review
- IR76b-expressing neurons inBiology letters · 2024Article
- Prediction error drives associative learning and conditioned behavior in a spiking model of Drosophila larva.iScience · 2024Article
- Rewarding Capacity of Optogenetically Activating a Giant GABAergic Central-Brain Interneuron in LarvalThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Reward expectations direct learning and drive operant matching inProceedings of the National Academy of Sciences of the United States of America · 2023Article
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- Minimal circuit motifs for second-order conditioning in the insect mushroom body.Frontiers in physiology · 2023Article
- Associative learning in larval and adult Drosophila is impaired by the dopamine-synthesis inhibitor 3-Iodo-L-tyrosine.Biology open · 2021Article
- The Role of Dopamine in Associative Learning in Drosophila: An Updated Unified Model.Neuroscience bulletin · 2021Review
- Dopaminergic mechanism underlying reward-encoding of punishment omission during reversal learning in Drosophila.Nature communications · 2021Article
- Identification ofOpen biology · 2020Article
- Controlling the behaviour of Drosophila melanogaster via smartphone optogenetics.Scientific reports · 2020Article
- Recurrent architecture for adaptive regulation of learning in the insect brain.Nature neuroscience · 2020Article
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Authors and funding
5 authors.
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Abstract
In insects, odours are coded by the combinatorial activation of ascending pathways, including their third-order representation in mushroom body Kenyon cells. Kenyon cells also receive intersecting input from ascending and mostly dopaminergic reinforcement pathways. Indeed, in Drosophila, presenting an odour together with activation of the dopaminergic mushroom body input neuron PPL1-01 leads to a weakening of the synapse between Kenyon cells and the approach-promoting mushroom body output neuron MBON-11. As a result of such weakened approach tendencies, flies avoid the shock-predicting odour in a subsequent choice test. Thus, increased activity in PPL1-01 stands for punishment, whereas reduced activity in MBON-11 stands for predicted punishment. Given that punishment-predictors can themselves serve as punishments of second order, we tested whether presenting an odour together with the optogenetic silencing of MBON-11 would lead to learned odour avoidance, and found this to be the case. In turn, the optogenetic activation of MBON-11 together with odour presentation led to learned odour approach. Thus, manipulating activity in MBON-11 can be an analogue of predicted, second-order reinforcement.
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