ArticleJournal of the Royal Society, Interface2019
An investigation of the glycosaminoglycan contribution to biaxial mechanical behaviours of porcine atrioventricular heart valve leaflets.
Article in Journal of the Royal Society, Interface, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- State-space formulations to understand the nonlinear viscoelastic mechanical behavior of tricuspid valve chordae tendineae.Applied mathematical modelling · 2026Article
- Structural valve deterioration is primarily caused by cyclic fatigue but not immune rejection.Frontiers in immunology · 2025Article
- Multiscale structure and function of the aortic valve apparatus.Physiological reviews · 2024Review
- MetaNO: How to Transfer Your Knowledge on Learning Hidden Physics.Computer methods in applied mechanics and engineering · 2023Article
- An investigation of how specimen dimensions affect biaxial mechanical characterizations with CellScale BioTester and constitutive modeling of porcine tricuspid valve leaflets.Journal of biomechanics · 2023Article
- Long-term histological effects of high-dose prednisolone administration on the mitral valve in normal Beagle dogs.Open veterinary journal · 2023Article
- A Physics-Guided Neural Operator Learning Approach to Model Biological Tissues From Digital Image Correlation Measurements.Journal of biomechanical engineering · 2022Article
- Anisotropicity and flexibility in trilayered microfibrous substrates promote heart valve leaflet tissue engineering.Biomedical materials (Bristol, England) · 2022Article
- Ex vivo experimental characterizations for understanding the interrelationship between tissue mechanics and collagen microstructure of porcine mitral valve leaflets.Journal of the mechanical behavior of biomedical materials · 2022Article
- Parameterization, geometric modeling, and isogeometric analysis of tricuspid valves.Computer methods in applied mechanics and engineering · 2021Article
- A pilot in silico modeling-based study of the pathological effects on the biomechanical function of tricuspid valves.International journal for numerical methods in biomedical engineering · 2020Article
- Mechanics and Microstructure of the Atrioventricular Heart Valve Chordae Tendineae: A Review.Bioengineering (Basel, Switzerland) · 2020Review
- An investigation of the effect of freezing storage on the biaxial mechanical properties of excised porcine tricuspid valve anterior leaflets.Journal of the mechanical behavior of biomedical materials · 2020Article
- An investigation of the glycosaminoglycan contribution to biaxial mechanical behaviours of porcine atrioventricular heart valve leaflets.Journal of the Royal Society, Interface · 2019Article
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 3 countries.
Funding
Abstract
The atrioventricular heart valve (AHV) leaflets have a complex microstructure composed of four distinct layers: atrialis, ventricularis, fibrosa and spongiosa. Specifically, the spongiosa layer is primarily proteoglycans and glycosaminoglycans (GAGs). Quantification of the GAGs' mechanical contribution to the overall leaflet function has been of recent focus for aortic valve leaflets, but this characterization has not been reported for the AHV leaflets. This study seeks to expand current GAG literature through novel mechanical characterizations of GAGs in AHV leaflets. For this characterization, mitral and tricuspid valve anterior leaflets (MVAL and TVAL, respectively) were: (i) tested by biaxial mechanical loading at varying loading ratios and by stress-relaxation procedures, (ii) enzymatically treated for removal of the GAGs and (iii) biaxially mechanically tested again under the same protocols as in step (i). Removal of the GAG contents from the leaflet was conducted using a 100 min enzyme treatment to achieve approximate 74.87% and 61.24% reductions of all GAGs from the MVAL and TVAL, respectively. Our main findings demonstrated that biaxial mechanical testing yielded a statistically significant difference in tissue extensibility after GAG removal and that stress-relaxation testing revealed a statistically significant smaller stress decay of the enzyme-treated tissue than untreated tissues. These novel findings illustrate the importance of GAGs in AHV leaflet behaviour, which can be employed to better inform heart valve therapeutics and computational models.
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