Evidence map›Paper›PMID 31266250›Full record

ArticleCancers2019

Extracapsular Lymph Node Involvement in Ovarian Carcinoma.

Sabine Heublein, Heiko Schulz, Frederik Marmé, Martin Angele, Bastian Czogalla, Alexander Burges, Sven Mahner, Doris Mayr, Udo Jeschke, Elisa Schmoeckel

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Sabine HeubleinDepartment of Obstetrics and Gynecology, Heidelberg University Hospital, Ruprecht-Karls-University of Heidelberg, 69120 Heidelberg, Germany. sabine.heublein@med.uni-heidelberg.de.
Heiko SchulzDepartment of Obstetrics and Gynecology, Klinikum der Universität München, Ludwig Maximilians University, 81377 Munich, Germany.
Frederik MarméDepartment of Obstetrics and Gynecology, Mannheim University Hospital, 68167 Mannheim, Germany.
Martin AngeleDepartment of Surgery, Klinikum der Universität München, Ludwig Maximilians University, 81377 Munich, Germany.
Bastian CzogallaDepartment of Obstetrics and Gynecology, Klinikum der Universität München, Ludwig Maximilians University, 81377 Munich, Germany.ORCID 0000-0001-6589-4736
Alexander BurgesDepartment of Obstetrics and Gynecology, Klinikum der Universität München, Ludwig Maximilians University, 81377 Munich, Germany.
Sven MahnerDepartment of Obstetrics and Gynecology, Klinikum der Universität München, Ludwig Maximilians University, 81377 Munich, Germany.
Doris MayrDepartment of Pathology, Ludwig Maximilians University, 81377 Munich, Germany.
Udo JeschkeDepartment of Obstetrics and Gynecology, Klinikum der Universität München, Ludwig Maximilians University, 81377 Munich, Germany.ORCID 0000-0003-2623-3235
Elisa SchmoeckelDepartment of Pathology, Ludwig Maximilians University, 81377 Munich, Germany.
Ludwig-Maximilians-Universität München · DEHeidelberg University · DEGerman Cancer Research Center · DE

Funding

Förderprogramm für Forschung und Lehre not applicable
6 · The paper itself

Abstract

Ovarian cancer (OC) spread to retro-peritoneal lymph nodes is detected in about one out of two patients at primary diagnosis. Whether the histologic pattern of lymph node involvement i.e., intra-(ICG) or extracapsular (ECG) cancer growth may affect patients' prognosis remains unknown. The aim of the current study was to analyze the prevalence of ECG and ICG in lymph node positive ovarian cancer. We further investigated whether ECG may be related to patients' prognosis and whether biomarkers expressed in the primary tumor may predict the pattern of lymph node involvement. Lymph node samples stemming from 143 OC patients were examined for presence of ECG. Capsular extravasation was tested for statistical association with clinico-pathological variables. We further tested 27 biomarkers that had been determined in primary tumor tissue for their potential to predict ECG in metastatic lymph nodes. ECG was detected in 35 (24.5%) of 143 lymph node positive patients. High grade (

Indexed as

extra-capsular growthlymph node metastasisovarian cancerprognosis

Identifiers

PMID31266250
PMCPMC6678603
OpenAlexW2954577663

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.