Evidence map›Paper›PMID 31266227›Full record

ArticleInternational journal of molecular sciences2019

Diagnostic Value of Cytomegalovirus IgM Antibodies at Birth in PCR-Confirmed Congenital Cytomegalovirus Infection.

Shohei Ohyama, Kazumichi Fujioka, Sachiyo Fukushima, Shinya Abe, Mariko Ashina, Toshihiko Ikuta, Kosuke Nishida, Hisayuki Matsumoto, Yuji Nakamachi, Kenji Tanimura and 2 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Cytomegalovirus Hepatitis in Immunocompetent and Immunocompromised Hosts.Journal of clinical and translational hepatology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Shohei OhyamaDepartment of Pediatrics, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.ORCID 0000-0003-3582-6390
Kazumichi FujiokaDepartment of Pediatrics, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan. fujiokak@med.kobe-u.ac.jp.ORCID 0000-0002-9913-6447
Sachiyo FukushimaDepartment of Pediatrics, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.
Shinya AbeDepartment of Pediatrics, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.
Mariko AshinaDepartment of Pediatrics, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.
Toshihiko IkutaDepartment of Pediatrics, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.ORCID 0000-0002-0516-5520
Kosuke NishidaDepartment of Pediatrics, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.
Hisayuki MatsumotoDepartment of Clinical Laboratory, Kobe University Hospital, Kobe 650-0017, Japan.
Yuji NakamachiDepartment of Clinical Laboratory, Kobe University Hospital, Kobe 650-0017, Japan.ORCID 0000-0002-1648-0606
Kenji TanimuraDepartment of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.
Hideto YamadaDepartment of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.ORCID 0000-0001-9839-2214
Kazumoto IijimaDepartment of Pediatrics, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.
Kobe University · JPKobe University Hospital · JP

Funding

Japan Society for the Promotion of Science 18K15710 and 19K17296Kawano Masanori Memorial Foundation for Promotion of Pediatrics. Wakate 2018
6 · The paper itself

Abstract

Although cytomegalovirus (CMV) DNA detection in urine is the standard method for diagnosing congenital cytomegalovirus infection (CCMVI), polymerase chain reaction (PCR) is not comprehensively available. Currently, the efficacy of CMV-specific IgM (CMV-IgM) and CMV-specific IgG (CMV-IgG) detection remains unclear. To determine the sensitivity and specificity of CMV-specific antibodies at birth, we investigated CMV-IgM and CMV-IgG titers in CCMVI cases and non-CCMVI controls, with confirmed diagnoses by urine quantitative real-time PCR within 3 weeks after birth. We included 174 infants with suspected CCMVI in whom serological testing was performed within the first 2 weeks after birth during 2012-2018. We classified the participants into a CCMVI group (

Indexed as

Antibodies, ViralCytomegalovirusCytomegalovirus InfectionsDNA, ViralDNA VirusesFemaleHumansImmunoglobulin MInfantInfant, NewbornMalePredictive Value of TestsProspective StudiesUrineAntibodies, ViralDNA, ViralImmunoglobulin Mcongenital cytomegalovirus infectioncytomegalovirus IgM antibodyquantitative real-time PCR

Identifiers

PMID31266227
PMCPMC6651178
OpenAlexW2954051415

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.