Evidence map›Paper›PMID 31266209›Full record

ArticlePharmaceutics2019

The Use of Artificial Gel Forming Bolalipids as Novel Formulations in Antimicrobial and Antifungal Therapy.

Nathalie Goergen, Matthias Wojcik, Simon Drescher, Shashank Reddy Pinnapireddy, Jana Brüßler, Udo Bakowsky, Jarmila Jedelská

Abstract read
In one paragraph

Article in Pharmaceutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Nanocarrier-hydrogel composite delivery systems for precision drug release.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2022
    Review
  4. Article
  5. Review
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nathalie GoergenDepartment of Pharmaceutics and Biopharmaceutics, University of Marburg, 35037 Marburg, Germany.
Matthias WojcikDepartment of Pharmaceutics and Biopharmaceutics, University of Marburg, 35037 Marburg, Germany.
Simon DrescherInstitute of Pharmacy, Biophysical Pharmacy, Martin Luther University Halle-Wittenberg, 06120 Halle (Saale), Germany.ORCID 0000-0002-3272-1721
Shashank Reddy PinnapireddyDepartment of Pharmaceutics and Biopharmaceutics, University of Marburg, 35037 Marburg, Germany.ORCID 0000-0003-4036-7619
Jana BrüßlerDepartment of Pharmaceutics and Biopharmaceutics, University of Marburg, 35037 Marburg, Germany.
Udo BakowskyDepartment of Pharmaceutics and Biopharmaceutics, University of Marburg, 35037 Marburg, Germany.
Jarmila JedelskáDepartment of Pharmaceutics and Biopharmaceutics, University of Marburg, 35037 Marburg, Germany. jedelska@mailer.uni-marburg.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The alarming growth of multi-drug resistant bacteria has led to a quest for alternative antibacterial therapeutics. One strategy to circumvent the already existing resistance is the use of photodynamic therapy. Antimicrobial photodynamic therapy (aPDT) involves the use of non-toxic photosensitizers in combination with light and in situ oxygen to generate toxic radical species within the microbial environment which circumvents the resistance building mechanism of the bacteria. Hydrogels are used ubiquitously in the biological and pharmaceutical fields, e.g., for wound dressing material or as drug delivery systems. Hydrogels formed by water-insoluble low-molecular weight gelators may potentially provide the much-needed benefits for these applications. Bolalipids are a superior example of such gelators. In the present work, two artificial bolalipids were used, namely PC-C32-PC and Me

Indexed as

aerogelantimicrobial photodynamic therapybolaform amphiphilic lipidsbolalipidschorioallantoic membrane modeldrug delivery systemhydrogelself-assembly

Identifiers

PMID31266209
PMCPMC6680875

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.