Evidence map›Paper›PMID 31265919›Full record

ArticleJournal of cardiac failure2019

Aberrant Brain Functional Connectivity Dynamic Responses to the Valsalva Maneuver in Heart Failure.

Xiaopeng Song, Bhaswati Roy, Milena Lai, Ashish Sahib, Gregg C Fonarow, Mary A Woo, Rajesh Kumar

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiac failure, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Xiaopeng SongDepartment of Anesthesiology, University of California at Los Angeles, Los Angeles, California 90095.
Bhaswati RoyUCLA School of Nursing, University of California at Los Angeles, Los Angeles, California 90095.
Milena LaiDepartment of Anesthesiology, University of California at Los Angeles, Los Angeles, California 90095.
Ashish SahibDepartment of Anesthesiology, University of California at Los Angeles, Los Angeles, California 90095.
Gregg C FonarowDivision of Cardiology, University of California at Los Angeles, Los Angeles, California 90095.
Mary A WooUCLA School of Nursing, University of California at Los Angeles, Los Angeles, California 90095.
Rajesh KumarDepartment of Anesthesiology, University of California at Los Angeles, Los Angeles, California 90095; Department of Radiological Sciences, University of California at Los Angeles, Los Angeles, California 90095; Department of Bioengineering, University of California at Los Angeles, Los Angeles, California 90095; Brain Research Institute, University of California at Los Angeles, Los Angeles, California 90095. Electronic address: rkumar@mednet.ucla.edu.
University of California, Los Angeles · US

Funding

Blood-Brain Barrier Dysfunction and Brain Injury in Heart FailureR01NR014669 · NINR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KUMAR, RAJESH, WOO, MARY ANN · 2014 to 2017
$1.9M
Central Autonomic Nervous System Regulation in Heart FailureR01NR013625 · NINR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KUMAR, RAJESH, WOO, MARY ANN · 2012 to 2015
$1.7M
NINR NIH HHS R01 NR013625NINR NIH HHS R01 NR014669
6 · The paper itself

Abstract

backgroundPatients with heart failure (HF) show abnormal autonomic activities, which may stem from altered functional connectivity (FC) between different brain sites. METHODS AND

resultsWe evaluate insular and cerebellar FC with other brain areas, before, during, and after the Valsalva challenge, with functional magnetic resonance imaging in 35 HF and 35 control subjects. Significant insular FC emerged with striatum, thalamus, and anterior cingulate. While left and right cerebellar cortices showed significant FC with each other constituting the cerebellum network, the insula and cerebellum networks showed significant negative FC with each other at baseline, challenge, and recovery phases. The challenge induced increased FC within the insula and the cerebellum networks in both HF and controls. However, patients with HF showed more increased insular network FC, but less enhanced cerebellar FC. During the recovery phase, the negative FC between the insular network and cerebellum enhanced significantly in controls, but not in HF. Lower left ventricle ejection fraction was correlated with lower insula network FC, and impaired negative FC between cerebellum and the insula network in HF.

conclusionsIncreased insular FC in patients with HF might contribute to exaggerated sympathetic tone. While impaired cerebellar FC and diminished negative interactions between cerebellum and insular systems may indicate impaired parasympathetic functions in HF.

Indexed as

CerebellumCerebral CortexHeart FailureAutonomic Nervous SystemConnectomeCorrelation of DataFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNeural PathwaysValsalva Maneuvercerebellumfunctional connectivityFunctional magnetic resonance imaginginsula

Identifiers

PMID31265919
PMCPMC7039687
OpenAlexW2954068363

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.