Evidence map›Paper›PMID 31265788›Full record

ArticleRadiation research2019

Sensitization of Vascular Endothelial Cells to Ionizing Radiation Promotes the Development of Delayed Intestinal Injury in Mice.

Chang-Lung Lee, Andrea R Daniel, Matt Holbrook, Jeremy Brownstein, Lorraine Da Silva Campos, Stephanie Hasapis, Yan Ma, Luke B Borst, Cristian T Badea, David G Kirsch

Open access · bronzeAbstract read
In one paragraph

Article in Radiation research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Cells · 2022
    Article
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Chang-Lung LeeDepartment of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710.
Andrea R DanielDepartment of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710.
Matt HolbrookDepartment of Center for In Vivo Microscopy, Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710.
Jeremy BrownsteinDepartment of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710.
Lorraine Da Silva CamposDepartment of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710.
Stephanie HasapisDepartment of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710.
Yan MaDepartment of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710.
Luke B BorstDepartment of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606.
Cristian T BadeaDepartment of Center for In Vivo Microscopy, Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710.
David G KirschDepartment of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710.
Duke Medical Center · USDuke University Hospital · USNorth Carolina State University · US

Funding

Women's Cancer Research ProgramP30CA014236 · NCI · DUKE UNIVERSITY · PI DONNA NIEDZWIECKI · 1985 to 2026
$174.8M
Somatostatin analogues as countermeasures against intestinal radiation toxicityU19AI067798 · NIAID · DUKE UNIVERSITY · PI CHAO, NELSON J. · 2005 to 2024
$82.1M
Advancing Cancer Therapy through Ground Breaking Research in Radiation BiologyR35CA197616 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI David Guy Kirsch · 2016 to 2026
$10.7M
MHC-bound, SIV-derived, CTL &HTL EpitopesR24RR015371 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI WATKINS, DAVID I · 2000 to 2011
$8.1M
INTEGRATED CENTER FOR IN VIVO MICROSCOPYP41EB015897 · NIBIB · DUKE UNIVERSITY · PI JOHNSON, GEORGE ALLAN · 2012 to 2017
$7.4M
The Duke Preclinical Research Resources for Quantitative Imaging BiomarkersU24CA220245 · NCI · DUKE UNIVERSITY · PI BADEA, CRISTIAN T · 2017 to 2021
$2.8M
Development of a New Generation Micro-CT imaging for Functional and Molecular Imaging of CancerR01CA196667 · NCI · DUKE UNIVERSITY · PI BADEA, CRISTIAN T · 2015 to 2019
$2.3M
NCI NIH HHS P30 CA014236NCI NIH HHS R01 CA196667NCI NIH HHS R35 CA197616NCI NIH HHS U24 CA220245NCRR NIH HHS R24 RR015371NIAID NIH HHS U19 AI067798NIBIB NIH HHS P41 EB015897
6 · The paper itself

Abstract

Exposure of the gastrointestinal (GI) tract to ionizing radiation can cause acute and delayed injury. However, critical cellular targets that regulate the development of radiation-induced GI injury remain incompletely understood. Here, we investigated the role of vascular endothelial cells in controlling acute and delayed GI injury after total-abdominal irradiation (TAI). To address this, we used genetically engineered mice in which endothelial cells are sensitized to radiation due to the deletion of the tumor suppressor p53. Remarkably, we found that

Indexed as

Radiation ToleranceAnimalsCapillary PermeabilityCell HypoxiaEndothelial CellsGene DeletionIntestinesMiceTime FactorsTumor Suppressor Protein p53Tumor Suppressor Protein p53

Identifiers

PMID31265788
PMCPMC6776243
OpenAlexW2954842147

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.