SynthesisPLoS medicine2019
Risks of stillbirth and neonatal death with advancing gestation at term: A systematic review and meta-analysis of cohort studies of 15 million pregnancies.
Synthesis in PLoS medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- A Systematic Review and Meta-Analysis of the Risk of Stillbirth, Perinatal and Neonatal Mortality in Immigrant Women.International journal of public health · 2022Pooled it
- Induction of labour at 41 weeks or expectant management until 42 weeks: A systematic review and an individual participant data meta-analysis of randomised trials.PLoS medicine · 2020Pooled it
- Induction of labour at or beyond 37 weeks' gestation.The Cochrane database of systematic reviews · 2020Pooled it
- Labor induction at 41Acta obstetricia et gynecologica Scandinavica · 2024Trial
- Comparison of Vaginal Birth Rate between Induction of Labour and Expectant Management at 40 Weeks in Women with a Previous Caesarean Section: A Pilot Randomized Controlled Trial.Journal of pregnancy · 2023Trial
- Induction of labour at 41 weeks versus expectant management and induction of labour at 42 weeks (SWEdish Post-term Induction Study, SWEPIS): multicentre, open label, randomised, superiority trial.BMJ (Clinical research ed.) · 2019Trial
- Dogmas in Obstetrics: Evidence-Based Standards, Clinical Judgement and Patient-Centred Care.Geburtshilfe und Frauenheilkunde · 2026Article
- Angiogenic Serum Biomarker Levels Are Related to Onset of Labour in Low-Risk Term and Post-Term Pregnancies: A Prospective Observational Cohort Study.BJOG : an international journal of obstetrics and gynaecology · 2026Observational
- Assessing the impact of indication for labor induction on delivery outcomes: a five-year cohort study.BMC pregnancy and childbirth · 2026Article
- The Halakhic Heartbeat at the Edge of Life: Navigating Maternal Brain Death and Fetal Life.Rambam Maimonides medical journal · 2026Review
- Article
- Causes of intrauterine fetal death (IUFD) in term singleton pregnancies (2014-2023): a retrospective study.Annals of medicine · 2025Article
- Timing of Term Births and Associated Mortality Risks: Ecological Analysis Across 28 European Countries.BJOG : an international journal of obstetrics and gynaecology · 2025Article
- Risk factors for neonatal mortality: an umbrella review of systematic reviews and meta-analyses.EClinicalMedicine · 2025Review
- Customized Birthweight Standard for the Population in the Republic of Kazakhstan.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2025Article
- Machine learning prediction models for mode of delivery in prolonged pregnancies in Sweden.Scientific reports · 2025Article
- Prediction of Small for Gestational Age and Growth-Restricted Neonates at 35 to 36 Weeks of Gestation: A Multicenter Cohort Study.Medicina (Kaunas, Lithuania) · 2025Article
- Prediction of small-for-gestational age and fetal growth restriction at routine ultrasound examination at 35-37 weeks' gestation.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2025Article
- Timing and mode of birth for women with sickle cell disease: A systematic review.Pregnancy (Hoboken, N.J.) · 2025Review
- Clinical examination for identifying low-risk pregnancies suitable for expectant management beyond 40-41 gestational weeks: maternal and fetal outcomes.Archives of gynecology and obstetrics · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite advances in healthcare, stillbirth rates remain relatively unchanged. We conducted a systematic review to quantify the risks of stillbirth and neonatal death at term (from 37 weeks gestation) according to gestational age. METHODS AND
findingsWe searched the major electronic databases Medline, Embase, and Google Scholar (January 1990-October 2018) without language restrictions. We included cohort studies on term pregnancies that provided estimates of stillbirths or neonatal deaths by gestation week. We estimated the additional weekly risk of stillbirth in term pregnancies that continued versus delivered at various gestational ages. We compared week-specific neonatal mortality rates by gestational age at delivery. We used mixed-effects logistic regression models with random intercepts, and computed risk ratios (RRs), odds ratios (ORs), and 95% confidence intervals (CIs). Thirteen studies (15 million pregnancies, 17,830 stillbirths) were included. All studies were from high-income countries. Four studies provided the risks of stillbirth in mothers of White and Black race, 2 in mothers of White and Asian race, 5 in mothers of White race only, and 2 in mothers of Black race only. The prospective risk of stillbirth increased with gestational age from 0.11 per 1,000 pregnancies at 37 weeks (95% CI 0.07 to 0.15) to 3.18 per 1,000 at 42 weeks (95% CI 1.84 to 4.35). Neonatal mortality increased when pregnancies continued beyond 41 weeks; the risk increased significantly for deliveries at 42 versus 41 weeks gestation (RR 1.87, 95% CI 1.07 to 2.86, p = 0.012). One additional stillbirth occurred for every 1,449 (95% CI 1,237 to 1,747) pregnancies that advanced from 40 to 41 weeks. Limitations include variations in the definition of low-risk pregnancy, the wide time span of the studies, the use of registry-based data, and potential confounders affecting the outcome.
conclusionsOur findings suggest there is a significant additional risk of stillbirth, with no corresponding reduction in neonatal mortality, when term pregnancies continue to 41 weeks compared to delivery at 40 weeks. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42015013785.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.