Evidence map›Paper›PMID 31265321›Full record

ArticleAmerican journal of respiratory and critical care medicine2019

Role of Glucosylceramide in Lung Endothelial Cell Fate and Emphysema.

Kengo Koike, Evgeny V Berdyshev, Andrew M Mikosz, Irina A Bronova, Anna S Bronoff, John P Jung, Erica L Beatman, Kevin Ni, Danting Cao, April K Scruggs and 2 more

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory and critical care medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 32 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Does Chronic Obstructive Pulmonary Disease Originate from Different Cell Types?American journal of respiratory cell and molecular biology · 2023
    Article
  6. Article
  7. Article
  8. Role of UDP-glucose ceramide glucosyltransferase in venous malformation.Frontiers in cell and developmental biology · 2023
    Article
  9. Article
  10. Cigarette smoke-induced airspace disease in mice develops independently of HIF-1α signaling in leukocytes.American journal of physiology. Lung cellular and molecular physiology · 2022
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Update in Chronic Obstructive Pulmonary Disease 2019.American journal of respiratory and critical care medicine · 2020
    Review
  16. Article
  17. Article
  18. FSTL-1 Attenuation Causes Spontaneous Smoke-Resistant Pulmonary Emphysema.American journal of respiratory and critical care medicine · 2020
    Article
  19. Endothelial Cell Death in Emphysema: More Sugarcoating Needed?American journal of respiratory and critical care medicine · 2019
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Kengo KoikeDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, National Jewish Health, Denver, Colorado; and.ORCID 0000-0003-4677-3589
Evgeny V BerdyshevDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, National Jewish Health, Denver, Colorado; and.ORCID 0000-0002-1376-0098
Andrew M MikoszDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, National Jewish Health, Denver, Colorado; and.
Irina A BronovaDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, National Jewish Health, Denver, Colorado; and.
Anna S BronoffDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, National Jewish Health, Denver, Colorado; and.
John P JungDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, National Jewish Health, Denver, Colorado; and.
Erica L BeatmanDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, National Jewish Health, Denver, Colorado; and.
Kevin NiDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, National Jewish Health, Denver, Colorado; and.
Danting CaoDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, National Jewish Health, Denver, Colorado; and.ORCID 0000-0002-3850-2837
April K ScruggsDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, National Jewish Health, Denver, Colorado; and.ORCID 0000-0003-3943-4212
Karina A SerbanDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, National Jewish Health, Denver, Colorado; and.ORCID 0000-0002-9372-3034
Irina PetracheDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, National Jewish Health, Denver, Colorado; and.ORCID 0000-0003-1094-2600
National Jewish Health · US

Funding

Ceramide-induced Lung Destruction in EmphysemaR01HL077328 · NHLBI · NATIONAL JEWISH HEALTH · PI PETRACHE, IRINA · 2006 to 2024
$8.0M
PREDOCTORAL TRAINING PROGRAM IN PHARMACOLOGYT32GM007635 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI DELL'ACQUA, MARK L · 1985 to 2023
$6.1M
Metabolic profiles of COPD phenotypesP20HL113445 · NHLBI · NATIONAL JEWISH HEALTH · PI BOWLER, RUSSELL PAUL · 2012 to 2016
$4.7M
Mannose binding lectin-dependent complement activation in emphysemaK08HL141770 · NHLBI · NATIONAL JEWISH HEALTH · PI SERBAN, KARINA · 2019 to 2023
$793k
Signaling Sphingolipids in COPDR03HL095440 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI BERDYSHEV, EVGENY V, PETRACHE, IRINA · 2008 to 2009
$169k
Role of TSG-6 mediated hyaluronic acid cross-linking in acute lung injuryF30HL136169 · NHLBI · NATIONAL JEWISH HEALTH · PI NI, KEVIN · 2018 to 2020
$129k
NHLBI NIH HHS F30 HL136169NHLBI NIH HHS P20 HL113445NHLBI NIH HHS R01 HL077328NHLBI NIH HHS R03 HL095440NIGMS NIH HHS T32 GM007635
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsAutophagyCell Culture TechniquesCell DeathDisease Models, AnimalEndothelial CellsGlucosylceramidesMicePulmonary EmphysemaSmokingGlucosylceramidesapoptosisautophagychronic obstructive pulmonary diseaseendotheliumsphingolipids

Identifiers

PMID31265321
PMCPMC6888657
OpenAlexW2955526532

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.