Evidence map›Paper›PMID 31265248›Full record

ArticleACS infectious diseases2019

Design and Application of a High-Throughput, High-Content Screening System for Natural Product Inhibitors of the Human Parasite

Jarrod B King, Adam C Carter, Wentao Dai, Jin Woo Lee, Yun-Seo Kil, Lin Du, Sara K Helff, Shengxin Cai, Brandt C Huddle, Robert H Cichewicz

Open access · greenAbstract read
In one paragraph

Article in ACS infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Rationally Minimizing Natural Product Libraries Using Mass Spectrometry.bioRxiv : the preprint server for biology · 2024
    Article
  5. Article
  6. Article
  7. Article
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  9. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Jarrod B KingNatural Products Discovery Group, Institute for Natural Products Applications and Research Technologies, Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center , University of Oklahoma , 101 Stephenson Parkway , Room 1000, Norman , Oklahoma 73019 , United States.
Adam C CarterNatural Products Discovery Group, Institute for Natural Products Applications and Research Technologies, Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center , University of Oklahoma , 101 Stephenson Parkway , Room 1000, Norman , Oklahoma 73019 , United States.
Wentao DaiNatural Products Discovery Group, Institute for Natural Products Applications and Research Technologies, Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center , University of Oklahoma , 101 Stephenson Parkway , Room 1000, Norman , Oklahoma 73019 , United States.
Jin Woo LeeNatural Products Discovery Group, Institute for Natural Products Applications and Research Technologies, Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center , University of Oklahoma , 101 Stephenson Parkway , Room 1000, Norman , Oklahoma 73019 , United States.
Yun-Seo KilNatural Products Discovery Group, Institute for Natural Products Applications and Research Technologies, Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center , University of Oklahoma , 101 Stephenson Parkway , Room 1000, Norman , Oklahoma 73019 , United States.
Lin DuNatural Products Discovery Group, Institute for Natural Products Applications and Research Technologies, Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center , University of Oklahoma , 101 Stephenson Parkway , Room 1000, Norman , Oklahoma 73019 , United States.ORCID 0000-0001-8751-4482
Sara K HelffNatural Products Discovery Group, Institute for Natural Products Applications and Research Technologies, Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center , University of Oklahoma , 101 Stephenson Parkway , Room 1000, Norman , Oklahoma 73019 , United States.
Shengxin CaiNatural Products Discovery Group, Institute for Natural Products Applications and Research Technologies, Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center , University of Oklahoma , 101 Stephenson Parkway , Room 1000, Norman , Oklahoma 73019 , United States.
Brandt C HuddleNatural Products Discovery Group, Institute for Natural Products Applications and Research Technologies, Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center , University of Oklahoma , 101 Stephenson Parkway , Room 1000, Norman , Oklahoma 73019 , United States.
Robert H CichewiczNatural Products Discovery Group, Institute for Natural Products Applications and Research Technologies, Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center , University of Oklahoma , 101 Stephenson Parkway , Room 1000, Norman , Oklahoma 73019 , United States.ORCID 0000-0003-0744-4117
University of Oklahoma · US

Funding

Early Stage Discovery of Natural Products Targeting Anaerobic Protozoal PathogenR33AI119713 · NIAID · UNIVERSITY OF OKLAHOMA · PI CICHEWICZ, ROBERT HENRY · 2017 to 2019
$1.4M
NIAID NIH HHS R33 AI119713
6 · The paper itself

Abstract

It is estimated that

Indexed as

Antiprotozoal AgentsBiological ProductsCell LineDrug DiscoveryFemaleFibroblastsFungiHigh-Throughput Screening AssaysHumansImage Processing, Computer-AssistedPyrrolidinonesQuinonesSensitivity and SpecificityTrichomonas vaginalisTrichomonas VaginitisAntiprotozoal AgentsBiological ProductsPyrrolidinonesQuinonestetramic acidfunginatural productsquinonestetramic acid

Identifiers

PMID31265248
PMCPMC10782576
OpenAlexW2949711204

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.