Evidence map›Paper›PMID 31265204›Full record

ArticleRespirology (Carlton, Vic.)2020

Improved diagnostic yield for lung nodules with digital tomosynthesis-corrected navigational bronchoscopy: Initial experience with a novel adjunct.

Matt Aboudara, Lance Roller, Otis Rickman, Robert J Lentz, Jasleen Pannu, Heidi Chen, Fabien Maldonado

3 registry-linked trialsAbstract read
PubMed Publisher
In one paragraph

Article in Respirology (Carlton, Vic.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05705544 nacompletednot on this mapstarted 2023, after this paper: background citation

Robotic Versus Electromagnetic Bronchoscopy for Pulmonary LesIon AssessmeNT: (the RELIANT Trial)

TypeinterventionalSponsorVanderbilt University Medical CenterRan2023 to 2024Enrolled447ConditionsPeripheral Pulmonary LesionsArmsILLUMISITE™ Platform (EMN bronchoscopy), Ion™ Endoluminal System (SSCB bronchoscopy)
NCT06654271 naactive not recruitingnot on this mapstarted 2024, after this paper: background citation

Robotic Versus Electromagnetic Bronchoscopy for Pulmonary LesIon AssessmeNT Using Integrated Intraprocedural Imaging: the RELIANT 2 Trial

TypeinterventionalSponsorVanderbilt University Medical CenterRan2024 to 2026Enrolled440ConditionsPeripheral Pulmonary Lesion, Lung Nodule, SolitaryArmsRobotic assisted bronchoscopy (RAB), Electromagnetic navigation bronchoscopy (ENB)
NCT07411989 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Shape-sensing Versus Electromagnetic Robotic Bronchoscopy for Evaluation of PulmoNary LEsions: the SERENE Trial

TypeinterventionalSponsorThe Cleveland ClinicRan2026 to 2028Enrolled346ConditionsPeripheral Pulmonary Lesions (PPLs), Lung NodulesArmsBronchoscopy for peripheral pulmonary lesion biopsy
3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Matt AboudaraDivision of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID https://orcid.org/0000-0001-8540-487X
Lance RollerDivision of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Otis RickmanDivision of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Robert J LentzDivision of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Jasleen PannuThe Division of Pulmonary Critical Care and Sleep Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Heidi ChenDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.
Fabien MaldonadoDivision of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectiveThe diagnostic yield of electromagnetic navigation bronchoscopy (ENB) is inferior to that of computed tomography (CT)-guided needle biopsy for pulmonary nodules. One explanation for this is divergence between the nodule location on the pre-procedure CT scan and its actual location during the procedure. Fluoroscopic ENB (F-ENB) consists of digital tomosynthesis using a conventional C-arm to re-register the target lesion based on near real-time imaging. We performed a retrospective review of ENB cases at our institution before and after introduction of F-ENB to assess diagnostic yield.

methodsAll consecutive ENB procedures performed at our institution from 25 December 2017 to 25 August 2018 were reviewed. F-ENB was introduced on 25 April 2018. Two cohorts were analysed: standard ENB (S-ENB) from 25 December 2017 to 24 April 2018 and F-ENB from 25 April 2018 to 25 August 2018. All procedural, demographic and diagnostic data were collected. Descriptive statistics, chi-square, Wilcoxon test and Student's t-test were used where appropriate. A multivariable regression analysis was performed to assess factors associated with diagnostic yield.

resultsA total of 101 and 67 nodules were biopsied in the S-ENB and F-ENB groups, respectively. Diagnostic yield was 54% in S-ENB cohort and 79% in the F-ENB group (P = 0.0019). Factors independently associated with a positive diagnosis were F-ENB and a positive radial ultrasound view (odds ratio (OR): 3.57, 95% CI: 1.56-8.18 and OR: 3.74, 95% CI: 1.37-11.05, respectively). Complications were minimal (pneumothorax: 1.5%).

conclusionThe use of F-ENB may increase the diagnostic yield of ENB and has a low complication rate.

Indexed as

AgedBronchoscopyFemaleFluoroscopyHumansImage-Guided BiopsyLungLung NeoplasmsMaleMiddle AgedMultiple Pulmonary NodulesPneumothoraxRetrospective StudiesTomography, X-Ray ComputedUltrasonographyfluoroscopylung nodulenavigational bronchoscopytomosynthesis

Identifiers

PMID31265204

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.