Evidence map›Paper›PMID 31265154›Full record

ArticleProteins2019

Estimation of model accuracy in CASP13.

Jianlin Cheng, Myong-Ho Choe, Arne Elofsson, Kun-Sop Han, Jie Hou, Ali H A Maghrabi, Liam J McGuffin, David Menéndez-Hurtado, Kliment Olechnovič, Torsten Schwede and 4 more

Abstract read
In one paragraph

Article in Proteins, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed.

  1. Article
  2. Article
  3. Recent advances and challenges in protein complex model accuracy estimation.Computational and structural biotechnology journal · 2024
    Review
  4. Protein folding: Funnel model revised.Computational and structural biotechnology journal · 2024
    Article
  5. Protein structure accuracy estimation using geometry-complete perceptron networks.Protein science : a publication of the Protein Society · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jianlin ChengDepartment of Electrical Engineering and Computer Science, University of Missouri, Columbia, Missouri.ORCID 0000-0003-0305-2853
Myong-Ho ChoeDepartment of Life Science, University of Science, Pyongyang, DPR Korea.
Arne ElofssonDepartment of Biochemistry and Biophysics and Science for Life Laboratory, Stockholm University, Stockholm, Sweden.ORCID 0000-0002-7115-9751
Kun-Sop HanDepartment of Life Science, University of Science, Pyongyang, DPR Korea.ORCID 0000-0001-6320-6573
Jie HouDepartment of Electrical Engineering and Computer Science, University of Missouri, Columbia, Missouri.
Ali H A MaghrabiSchool of Biological Sciences, University of Reading, Reading, UK.
Liam J McGuffinSchool of Biological Sciences, University of Reading, Reading, UK.ORCID 0000-0003-4501-4767
David Menéndez-HurtadoDepartment of Biochemistry and Biophysics and Science for Life Laboratory, Stockholm University, Stockholm, Sweden.
Kliment OlechnovičInstitute of Biotechnology, Life Sciences Center, Vilnius University, Vilnius, Lithuania.
Torsten SchwedeBiozentrum, University of Basel, Basel, Switzerland.ORCID 0000-0003-2715-335X
Gabriel StuderBiozentrum, University of Basel, Basel, Switzerland.
Karolis UzielaDepartment of Biochemistry and Biophysics and Science for Life Laboratory, Stockholm University, Stockholm, Sweden.ORCID 0000-0003-2232-3006
Česlovas VenclovasInstitute of Biotechnology, Life Sciences Center, Vilnius University, Vilnius, Lithuania.ORCID 0000-0002-4215-0213
Björn WallnerDepartment of Physics, Chemistry, and Biology, Bioinformatics Division, Linköping University, Linköping, Sweden.ORCID 0000-0002-3772-8279

Funding

Integrated Prediction of Protein Struture at 1D, 2D and 3D LevelsR01GM093123 · NIGMS · UNIVERSITY OF MISSOURI-COLUMBIA · PI CHENG, JIANLIN · 2010 to 2023
$3.8M
NIGMS NIH HHS R01 GM093123NIH HHS R01GM093123
6 · The paper itself

Abstract

Methods to reliably estimate the accuracy of 3D models of proteins are both a fundamental part of most protein folding pipelines and important for reliable identification of the best models when multiple pipelines are used. Here, we describe the progress made from CASP12 to CASP13 in the field of estimation of model accuracy (EMA) as seen from the progress of the most successful methods in CASP13. We show small but clear progress, that is, several methods perform better than the best methods from CASP12 when tested on CASP13 EMA targets. Some progress is driven by applying deep learning and residue-residue contacts to model accuracy prediction. We show that the best EMA methods select better models than the best servers in CASP13, but that there exists a great potential to improve this further. Also, according to the evaluation criteria based on local similarities, such as lDDT and CAD, it is now clear that single model accuracy methods perform relatively better than consensus-based methods.

Indexed as

Computational BiologyProtein ConformationSoftwareAlgorithmsDatabases, ProteinModels, MolecularProtein FoldingProteinsSequence AlignmentSequence Analysis, ProteinProteins

Identifiers

PMID31265154
PMCPMC6851425

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.