ArticleACS nano2019
Designing Higher Resolution Self-Assembled 3D DNA Crystals via Strand Terminus Modifications.
Article in ACS nano, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- A synthetic cell microreactor with two types of interacting dynamic DNA-based pores.Nature chemistry · 2026Article
- Crystallographic Study of DNA T-Junction via Crystal Engineering.Angewandte Chemie (International ed. in English) · 2025Article
- Counterions influence the isothermal self-assembly of DNA nanostructures.Science advances · 2025Article
- Crystalline Assemblies of DNA Nanostructures and Their Functional Properties.Angewandte Chemie (International ed. in English) · 2025Review
- Six-Letter DNA Nanotechnology: Incorporation ofNano letters · 2024Article
- Tuning Chemical DNA Ligation within DNA Crystals and Protein-DNA Cocrystals.ACS nanoscience Au · 2024Article
- Creation of Metal-Complex-Integrated Tensegrity Triangle DNA Crystals.Molecules (Basel, Switzerland) · 2024Article
- Engineering tertiary chirality in helical biopolymers.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Programming crystallization kinetics of self-assembled DNA crystals with 5-methylcytosine modification.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Exploring the Potential of Three-Dimensional DNA Crystals in Nanotechnology: Design, Optimization, and Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Review
- Recent Advances in DNA Origami-Engineered Nanomaterials and Applications.Chemical reviews · 2023Review
- The Formation and Displacement of Ordered DNA Triplexes in Self-Assembled Three-Dimensional DNA Crystals.Journal of the American Chemical Society · 2023Article
- High-throughput single-molecule quantification of individual base stacking energies in nucleic acids.Nature communications · 2023Article
- The wending rhombus: Self-assembling 3D DNA crystals.Biophysical journal · 2022Review
- Tetraphenylethylene-DNA conjugates: influence of sticky ends and DNA sequence length on the supramolecular assembly of AIE-active vesicles.Organic & biomolecular chemistry · 2022Article
- Reconfigurable Two-Dimensional DNA Lattices: Static and Dynamic Angle Control.Angewandte Chemie (International ed. in English) · 2021Article
- DNA-Grafted 3D Superlattice Self-Assembly.International journal of molecular sciences · 2021Review
- Hybrid DNA/RNA nanostructures with 2'-5' linkages.Nanoscale · 2020Article
- Bottom-Up Self-Assembly Based on DNA Nanotechnology.Nanomaterials (Basel, Switzerland) · 2020Review
- Complex assemblies and crystals guided by DNA.Nature materials · 2020Article
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14 authors.
Funding
Abstract
DNA tensegrity triangles self-assemble into rhombohedral three-dimensional crystals via sticky ended cohesion. Crystals containing two-nucleotide (nt) sticky ends (GA:TC) have been reported previously, and those crystals diffracted to 4.9 Å at beamline NSLS-I-X25. Here, we analyze the effect of varying sticky end lengths and sequences as well as the impact of 5'- and 3'-phosphates on crystal formation and resolution. Tensegrity triangle motifs having 1-, 2-, 3-, and 4-nt sticky ends all form crystals. X-ray diffraction data from the same beamline reveal that the crystal resolution for a 1-nt sticky end (G:C) and a 3-nt sticky end (GAT:ATC) were 3.4 and 4.2 Å, respectively. Resolutions were determined from complete data sets in each case. We also conducted trials that examined every possible combination of 1-nucleotide and 2-nucleotide sticky-ended phosphorylated strands and successfully crystallized all 16 possible combinations of strands. We observed the position of the 5'-phosphate on either the crossover (1), helical (2), or central strand (3) affected the resolution of the self-assembled crystals for the 2-turn monomer (3.0 Å for 1-2P-3P) and 2-turn dimer sticky ended (4.1 Å for 1-2-3P) systems. We have also examined the impact of the identity of the base flanking the sticky ends as well as the use of 3'-phosphate. We conclude that crystal resolution is not a simple consequence of the thermodynamics of the direct nucleotide pairing interactions involved in molecular cohesion in this system.
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