Evidence map›Paper›PMID 31264493›Full record

Trial reportLeukemia & lymphoma2019

Myosteatosis in adolescents and young adults treated for acute lymphoblastic leukemia.

Nicole M Mueske, Steven D Mittelman, Tishya A L Wren, Vicente Gilsanz, Etan Orgel

Open access · greenAbstract readClinical Trial, Phase IIRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Leukemia & lymphoma, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Nicole M MueskeChildren's Orthopaedic Center, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Steven D MittelmanKeck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Tishya A L WrenChildren's Orthopaedic Center, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Vicente GilsanzKeck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Etan OrgelKeck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Children's Hospital of Los Angeles · US

Funding

Southern California Clinical and Translational Science InstituteUL1TR001855 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Thomas A Buchanan, Michele D. Kipke · 2016 to 2026
$81.3M
Southern California Clinical and Translational Science InstituteUL1TR000130 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BUCHANAN, THOMAS A · 2012 to 2015
$36.0M
Risk Factors for Osteoporosis in Children & Adolescents with MyelomeningoceleR01HD059826 · NICHD · CHILDREN'S HOSPITAL OF LOS ANGELES · PI WREN, TISHYA A L · 2010 to 2014
$2.4M
Adipocytes are Important Players in the Acute Lymphoblastic Leukemia MicroenvironmentR01CA201444 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MITTELMAN, STEVEN DAVID · 2016 to 2020
$1.9M
NCATS NIH HHS UL1 TR000130NCATS NIH HHS UL1 TR001855NCI NIH HHS R01 CA201444NICHD NIH HHS R01 HD059826
6 · The paper itself

Abstract

Myosteatosis refers to fat deposition within muscle and is linked to risk of cardiovascular disease and metabolic disorders. Though these comorbidities are common during and after therapy for acute lymphoblastic leukemia (ALL), little is known about tissue distribution, including myosteatosis, in this population. Using quantitative computed tomography, we assessed the impact of ALL therapy on bone, muscle, subcutaneous, and muscle-associated (MA) fat in 12 adolescents and young adults (AYA) treated for ALL as compared to a healthy control group without ALL (

Indexed as

Absorptiometry, PhotonAdipose TissueAdolescentAntineoplastic Combined Chemotherapy ProtocolsBone and BonesChildFemaleHumansMaleMuscle, SkeletalMuscular DiseasesPrecursor Cell Lymphoblastic Leukemia-LymphomaRemission InductionSarcopeniaTomography, X-Ray ComputedUnited StatesAdipose tissueintermuscular fatintramuscular fatpediatric leukemiasarcopenia

Identifiers

PMID31264493
PMCPMC6923569
OpenAlexW2955276790

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.