ArticleGenes, brain, and behavior2019
Disrupted-in-schizophrenia 1 functional polymorphisms and D
Tarik Dahoun, Matthew M Nour, Rick A Adams, Svenja Trossbach, Sang H Lee, Hamel Patel, Charles Curtis, Carsten Korth, Oliver D Howes
Open access · greenAbstract read
In one paragraphArticle in Genes, brain, and behavior, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 94% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 2 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
9 authors at 4 institutions in 2 countries.
Tarik DahounPsychiatric Imaging Group, Robert Steiner MRI Unit, MRC London Institute of Medical Sciences, Hammersmith Hospital, London, UK.ORCID 0000-0002-9831-4926 Matthew M NourPsychiatric Imaging Group, Robert Steiner MRI Unit, MRC London Institute of Medical Sciences, Hammersmith Hospital, London, UK.
Rick A AdamsPsychiatric Imaging Group, Robert Steiner MRI Unit, MRC London Institute of Medical Sciences, Hammersmith Hospital, London, UK.
Svenja TrossbachDepartment Neuropathology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Sang H LeeDepartment of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Hamel PatelDepartment of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Charles CurtisInstitute of Clinical Sciences, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, UK.
Carsten KorthDepartment Neuropathology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Oliver D HowesPsychiatric Imaging Group, Robert Steiner MRI Unit, MRC London Institute of Medical Sciences, Hammersmith Hospital, London, UK.
King's College London · GBHammersmith Hospital · GBHeinrich Heine University Düsseldorf · DEWellcome Centre for Human Neuroimaging · GB
Funding
Department of HealthMedical Research Council G0700995Medical Research Council MC-A656-5QD30Medical Research Council MC_U120097115Medical Research Council MR/L022176/1Medical Research Council MR/N026063/1Medical Research Council MR/N027078/1Wellcome Trust 094849Wellcome Trust 094849/Z/10/Z
6 · The paper itselfAbstract
The disrupted-in-schizophrenia 1 (DISC1) protein has been implicated in a range of biological mechanisms underlying chronic mental disorders such as schizophrenia. Schizophrenia is associated with abnormal striatal dopamine signalling, and all antipsychotic drugs block striatal dopamine 2/3 receptors (D
Indexed as
Polymorphism, Single NucleotideAdultCorpus StriatumFemaleHumansMaleNerve Tissue ProteinsOxazinesPositron-Emission TomographyProtein BindingRadiopharmaceuticalsReceptors, DopamineDISC1 protein, humannaxagolideNerve Tissue ProteinsOxazinesRadiopharmaceuticalsReceptors, DopamineArg264GlnDISC1dopamineLeu607PhePETPHNOpolymorphismpsychosisreceptorSer704Cys
Identifiers
PMID31264367
PMCPMC7105392
OpenAlexW2956034373
What OpenQuestion holds
Textmetadata
LicenceTDM
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