Evidence map›Paper›PMID 31264186›Full record

SynthesisSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2019

Is photobiomodulation therapy effective in reducing pain caused by toxicities related to head and neck cancer treatment? A systematic review.

Mariana de Pauli Paglioni, Carolina Guimarães Bonfim Alves, Elisa Kauark Fontes, Marcio Ajudarte Lopes, Ana Carolina Prado Ribeiro, Thaís Bianca Brandão, Cesar Augusto Migliorati, Alan Roger Santos-Silva

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Cost-effectiveness of photobiomodulation therapy for the prevention and management of cancer treatment toxicities: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
    Pooled it
  3. Trial
  4. Article
  5. Review
  6. Review
  7. Clinical use of photobiomodulation as a supportive care during radiation therapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Article
  8. Review
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Mariana de Pauli PaglioniOral Diagnosis Department, Semiology and Pathology Areas, Piracicaba Dental School, University of Campinas (UNICAMP), 901, Av. Limeira, Areão, Piracicaba, São Paulo, 13414-903, Brazil.
Carolina Guimarães Bonfim AlvesOral Diagnosis Department, Semiology and Pathology Areas, Piracicaba Dental School, University of Campinas (UNICAMP), 901, Av. Limeira, Areão, Piracicaba, São Paulo, 13414-903, Brazil.
Elisa Kauark FontesOral Diagnosis Department, Semiology and Pathology Areas, Piracicaba Dental School, University of Campinas (UNICAMP), 901, Av. Limeira, Areão, Piracicaba, São Paulo, 13414-903, Brazil.
Marcio Ajudarte LopesOral Diagnosis Department, Semiology and Pathology Areas, Piracicaba Dental School, University of Campinas (UNICAMP), 901, Av. Limeira, Areão, Piracicaba, São Paulo, 13414-903, Brazil.
Ana Carolina Prado RibeiroOral Diagnosis Department, Semiology and Pathology Areas, Piracicaba Dental School, University of Campinas (UNICAMP), 901, Av. Limeira, Areão, Piracicaba, São Paulo, 13414-903, Brazil.
Thaís Bianca BrandãoDental Oncology Service, São Paulo State Cancer Institute (ICESP-FMUSP), São Paulo, Brazil.
Cesar Augusto MiglioratiCollege of Dentistry, University of Florida, Gainesville, FL, USA.
Alan Roger Santos-SilvaOral Diagnosis Department, Semiology and Pathology Areas, Piracicaba Dental School, University of Campinas (UNICAMP), 901, Av. Limeira, Areão, Piracicaba, São Paulo, 13414-903, Brazil. alan@unicamp.br.ORCID http://orcid.org/0000-0003-2040-6617
Universidade Estadual de Campinas (UNICAMP) · BRInstituto do Câncer do Estado de São Paulo · BRUniversity of Florida · US

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2012/06138-1Fundação de Amparo à Pesquisa do Estado de São Paulo 2013/18402-8Fundação de Amparo à Pesquisa do Estado de São Paulo 2018/02233-6
6 · The paper itself

Abstract

Photobiomodulation therapy (PBMT) has been considered an effective method for preventing and managing certain cancer-related toxicities in head and neck cancer (HNC) patients treated with radiotherapy and chemotherapy. However, the potential effects of PBMT on pain control and analgesia resulting from these toxicities is still controversial. The aim of this systematic review was to compile available evidence of the effects of PMBT on pain control and reduced use of analgesics in HNC patients. We searched three indexed databases: MEDLINE/PubMed, Embase, and Scopus. The databases were reviewed up to and including December 2018. Only human clinical studies in English language were selected. Information was only available for mucositis and radiodermatitis. Fifteen out of 1112 studies met the inclusion criteria (14 for oral mucositis (OM) and 1 for radiodermatitis). From the 14 studies involving the prevention and treatment of OM, 10 had the study subjects compared to a placebo group. Of these 10 studies, all but 1 showed statistically significant difference related to pain control favoring the PBMT group. The study that compared PBMT with other treatment modality showed better results in pain control with PBMT. It appears that PBMT application frequency and potency impact on pain control. The only study involving the prevention and treatment of radiodermatitis was compared to placebo arm and showed statistically significant difference related to pain control favoring the PBMT group. Seven studies compared the need of analgesic medication between PBMT and placebo groups. Of these, five studies showed that the use of analgesic medication was significantly higher in the placebo group. The current evidence supports that PBMT is effective in pain control resulting from OM and radiodermatitis and may also reduce the need for analgesics. The evidence is not yet available of the effects of PBMT in other HNC treatment-related toxicities.

Indexed as

FemaleHead and Neck NeoplasmsHumansLow-Level Light TherapyMalePainStomatitisHead and neck cancerPainPhotobiomodulation therapySystematic review

Identifiers

PMID31264186
OpenAlexW2954954694

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.