Evidence map›Paper›PMID 31264177›Full record

ArticleObesity surgery2019

Treatment of Severe Protein Malnutrition After Bariatric Surgery.

Carlijn Kuin, Floor den Ouden, Hans Brandts, Laura Deden, Eric Hazebroek, Marcel van Borren, Hans de Boer

Abstract read
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In one paragraph

Article in Obesity surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 3 pooled it
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Article
  5. Review
  6. Article
  7. Severe Hypoalbuminaemia after Roux-En-Y Gastric Bypass: A Diagnosis of Exclusion.European journal of case reports in internal medicine · 2025
    Article
  8. Nutrition and Patient Follow-up in Bariatric Surgery.The Eurasian journal of medicine · 2023
    Article
  9. Precision nutrition in the context of bariatric surgery.Reviews in endocrine & metabolic disorders · 2023
    Review
  10. Review
  11. Article
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Carlijn KuinDivision of Human Nutrition, Wageningen University Research, Wageningen, The Netherlands.
Floor den OudenDivision of Human Nutrition, Wageningen University Research, Wageningen, The Netherlands.
Hans BrandtsDepartment of Clinical Nutrition, Rijnstate Hospital, Arnhem, The Netherlands.
Laura DedenDepartment of Surgery, Rijnstate Hospital, Arnhem, The Netherlands.ORCID 0000-0002-1243-5111
Eric HazebroekDepartment of Surgery, Rijnstate Hospital, Arnhem, The Netherlands.
Marcel van BorrenDepartment of Clinical Chemistry, Rijnstate Hospital, Arnhem, The Netherlands.
Hans de BoerDepartment of Internal Medicine, Rijnstate Hospital, Wagnerlaan 55, 6800, TA, Arnhem, The Netherlands. hdeboer@rijnstate.nl.
Rijnstate Hospital · NLWageningen University & Research · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSevere protein malnutrition, with a serum albumin < 25 g/L, is one of the complications that may develop after bariatric surgery. It is associated with increased morbidity and mortality and requires timely diagnosis and appropriate treatment to prevent rapid clinical deterioration. However, evidence-based recommendations for a specific treatment approach are currently not available. The present study describes the efficacy of a newly developed treatment regimen for post-bariatric patients presenting with severe hypoalbuminemia.

methodsA single-centre, retrospective analysis of eleven post-bariatric patients presenting with severe hypoalbuminemia, treated with continuous 24 h nasal-jejunal tube feeding of a medium chain triglyceride (MCT) formulation in combination with pancreatic enzyme supplementation every 3 h.

resultsDuration of tube feeding ranged from 25 to 156 days (median 64 days) and pancreatic enzyme was supplemented for 22-195 days (median 75 days). An increase in serum albumin levels of 5 g/L and 10 g/L was achieved after a median period of 20 (range 6-26 days) and 36 days (range 21-57 days), respectively. Albumin levels were > 35 g/L after a median period of 58 days (range 44-171 days).

conclusionIn this case series, a continuous 24-h nasal-jejunal MCT tube feed combined with frequent pancreatic enzyme supplementation was effective in all patients presenting with severe post-bariatric hypoalbuminemia and was not associated with adverse effects.

Indexed as

Enteral NutritionAdultAgedBariatric SurgeryEnzyme Replacement TherapyFemaleGastrointestinal AgentsHumansHypoalbuminemiaMaleMiddle AgedPancreatinPostoperative ComplicationsProtein-Energy MalnutritionRetrospective StudiesGastrointestinal AgentsPancreatinBariatric surgeryHyperammonemiaHypoalbuminemiaNutritionPancreatic enzymesTube feeding

Identifiers

PMID31264177
OpenAlexW2953984608

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.