Evidence map›Paper›PMID 31264142›Full record

ArticleJournal of endocrinological investigation2020

Anti-gastric parietal cell antibodies for autoimmune gastritis screening in juvenile autoimmune thyroid disease.

V Calcaterra, C Montalbano, E Miceli, O Luinetti, R Albertini, F Vinci, C Regalbuto, D Larizza

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In one paragraph

Article in Journal of endocrinological investigation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Autoimmune gastritis.Nature reviews. Disease primers · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

V CalcaterraPediatric and Adolescent Unit, Department of Internal Medicine, University of Pavia, Pavia, Italy. valeria.calcaterra@unipv.it.
C MontalbanoPediatric and Adolescent Unit, Department of Internal Medicine, University of Pavia, Pavia, Italy.
E MiceliFirst Department of Internal Medicine, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
O LuinettiDepartment of Molecular Medicine, University of Pavia, Pavia, Italy.
R AlbertiniLaboratory of Clinical Chemistry, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
F VinciPediatric and Adolescent Unit, Department of Internal Medicine, University of Pavia, Pavia, Italy.
C RegalbutoPediatric and Adolescent Unit, Department of Internal Medicine, University of Pavia, Pavia, Italy.
D LarizzaPediatric and Adolescent Unit, Department of Internal Medicine, University of Pavia, Pavia, Italy.
Policlinico San Matteo Fondazione · ITUniversity of Pavia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivePatients with autoimmune thyroid disease (ATD) have a higher prevalence of autoimmune gastritis (AIG) compared with the general population. The association between ATD and AIG is poorly characterized in the pediatric age. We reviewed the prevalence of anti-gastric parietal cell antibodies (PCA) in young patients with ATD to evaluate its usefulness as a marker for AIG screening.

methodsWe evaluated 220 children and adolescents (11.28 ± 6.37 years) with ATD (186 with autoimmune thyroiditis (AT) and 34 with Graves' disease (GD). At ATD diagnosis and annually thereafter, blood counts and PCA levels were measured. In patients positive for PCA, plasma gastrin, chromogranin A, vitamin B

resultsPCA positivity was detected in ten (4.5%) subjects (5F/5M; 12.6 ± 3.4 years). The prevalence of PCA positivity was not significantly different in the comparison of GD and AT patients (p = 0.9). PCA positivity was detected after 2.7 ± 2.7 years of follow-up in AT and 4.4 ± 4.0 years in GD (p = 0.4). Autoantibody positivity was more prevalent in female patients, in both AT and GD (p = 0.02 and p = 0.03, respectively). At detection of PCA positivity, five out of ten PCA-positive patients had iron deficiency, four vitamin B

conclusionIn the juvenile population, ATD and AIG may also be associated. PCA screening is useful to detect subjects at risk for this condition. Due to the longer life expectancy of the pediatric population and considering the relatively high risk of malignant transformation, early surveillance monitoring is mandatory for children and adolescents with ATD.

Indexed as

AdolescentAutoantibodiesBiomarkersChildChild, PreschoolFemaleFollow-Up StudiesGastritisGraves DiseaseHumansMaleParietal Cells, GastricPrognosisThyroiditis, AutoimmuneAutoantibodiesBiomarkersAnti-gastric parietal cell antibodiesAutoimmune gastritisAutoimmune thyroid diseaseChildrenScreening

Identifiers

PMID31264142
OpenAlexW2954247614

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.