Evidence map›Paper›PMID 31264141›Full record

ArticleJournal of endocrinological investigation2020

Association between iodine intake and thyroid autoantibodies: a cross-sectional study of 7073 early pregnant women in an iodine-adequate region.

J Sun, D Teng, C Li, S Peng, J Mao, W Wang, X Xie, C Fan, C Li, T Meng and 5 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of endocrinological investigation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.

  1. Pooled it
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  11. Iodine nutrition optimization: are there risks for thyroid autoimmunity?Journal of endocrinological investigation · 2021
    Review
  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

J SunDepartment of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, China Medical University, No. 155, North Nanjing Street, Heping District, Shenyang, 110001, China.
D TengDepartment of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, China Medical University, No. 155, North Nanjing Street, Heping District, Shenyang, 110001, China.
C LiDepartment of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, China Medical University, No. 155, North Nanjing Street, Heping District, Shenyang, 110001, China.
S PengDepartment of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, China Medical University, No. 155, North Nanjing Street, Heping District, Shenyang, 110001, China.
J MaoDepartment of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, China Medical University, No. 155, North Nanjing Street, Heping District, Shenyang, 110001, China.
W WangDepartment of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, China Medical University, No. 155, North Nanjing Street, Heping District, Shenyang, 110001, China.
X XieDepartment of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, China Medical University, No. 155, North Nanjing Street, Heping District, Shenyang, 110001, China.
C FanDepartment of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, China Medical University, No. 155, North Nanjing Street, Heping District, Shenyang, 110001, China.
C LiDepartment of Obstetrics and Gynecology, Shenyang Fifth People's Hospital, Shenyang, 110023, China.
T MengDepartment of Obstetrics and Gynecology, The First Hospital of China Medical University, Shenyang, 110001, China.
S ZhangDepartment of Endocrinology, No. 202 Hospital of People's Liberation Army, Shenyang, 110003, China.
J DuDepartment of Endocrinology, The First Affiliated Hospital of Dalian Medical University, Dalian, 116044, China.
Z GaoDepartment of Endocrinology, Dalian Municipal Central Hospital Affiliated of Dalian Medical University, Dalian, 116033, China.
Z ShanDepartment of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, China Medical University, No. 155, North Nanjing Street, Heping District, Shenyang, 110001, China. cmushanzhongyan@163.com.
W TengDepartment of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, China Medical University, No. 155, North Nanjing Street, Heping District, Shenyang, 110001, China. twp@vip.163.com.
China Medical University · CNDalian Medical University · CNDalian Municipal Central Hospital · CNShenyang Fifth People Hospital · CN

Funding

Department of Science and Technology, Liaoning Province government 2011225023Department of Science and Technology, Liaoning Province government 2012225020Ministry of Health of the People's Republic of China 201002002Ministry of Science and Technology of the People's Republic of China 2011CB512112National Natural Science Foundation of China 81170730the Guanghua Science and Technology Foundation of China 2007-02the important platform of science and technology for the universities in Liaoning Province 16010the Research Foundation innovative team from the Advanced Educational Institute LT 2012015the Research Foundation of Key Laboratory of Endocrine Diseases, Department of Science and Technology, Shenyang Government, Liaoning Province, China F11-244-1-00the Twelve-Five Science and Technology Support Program No2014BAI06B02
6 · The paper itself

Abstract

purposeThe association between iodine intake and thyroid autoimmunity has been debated, especially in pregnant women. This study aimed to investigate thyroid autoantibodies and their association with iodine intake and hypothyroidism in early pregnancy.

methods7073 early pregnant women from an iodine-sufficient region participated in this study. Urinary iodine concentrations (UICs) were measured using an ammonium persulfate method. Serum thyroid peroxidase antibody (TPOAb), thyroglobulin antibody (TgAb), thyroid-stimulating hormone (TSH), free thyroxine (FT4), and Tg were determined using an electrochemiluminescence immunoassay.

resultsIodine deficiency (UIC < 100 μg/L) was associated with higher risks of TPOAb positivity [adjusted odds ratio (aOR) = 1.64, 95% confidence interval [CI] (1.29-2.08)] and TgAb positivity [aOR = 1.44, 95% CI (1.16-1.80)]. Women with isolated TPOAb positivity, isolated TgAb positivity, or both TPOAb and TgAb positivity had a 14.64-fold, 7.83-fold, and 44.69-fold increased risk of overt hypothyroidism, and a 4.36-fold, 2.86-fold, and 6.26-fold increased risk of subclinical hypothyroidism, respectively. Moreover, the risks of overt and subclinical hypothyroidism in women with a high TPOAb titer were 16.99 and 4.80 times that in TPOAb-negative women, respectively. The risk of overt hypothyroidism in women with a high TgAb titer was 6.97 times that in TgAb-negative women.

conclusionsOur work demonstrates that iodine deficiency during early pregnancy is an independent risk factor for both TPOAb positivity and TgAb positivity. Furthermore, positivity for both autoantibodies and a high thyroid autoantibody titer are associated with significantly higher risks of overt and subclinical hypothyroidism.

Indexed as

AdultAnti-Infective Agents, LocalAutoantibodiesBiomarkersCross-Sectional StudiesFemaleFollow-Up StudiesHumansHypothyroidismIodinePregnancyPrognosisThyroid HormonesYoung AdultAnti-Infective Agents, Localanti-thyroglobulinAutoantibodiesBiomarkersIodineThyroid Hormonesthyroid microsomal antibodiesEarly pregnancyHypothyroidismIodine intakeThyroid autoantibodies

Identifiers

PMID31264141
OpenAlexW3037076032

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.