ArticleMikrochimica acta2019
Two colorimetric ampicillin sensing schemes based on the interaction of aptamers with gold nanoparticles.
Article in Mikrochimica acta, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 38 citations in OpenAlex.
- Enzyme-free biosensor utilizing chitosan-capped ZnS doped by Mn nanomaterials for tetracycline hydrochloride detection.Heliyon · 2024Article
- Ampicillin detection using absorbance biosensors utilizing Mn-doped ZnS capped with chitosan micromaterials.Heliyon · 2024Article
- Dual-channel fluorescent sensors based on chitosan-coated Mn-doped ZnS micromaterials to detect ampicillin.Scientific reports · 2024Article
- Nano optical and electrochemical sensors and biosensors for detection of narrow therapeutic index drugs.Mikrochimica acta · 2021Review
- Advances in Gold Nanoparticles-Based Colorimetric Aptasensors for the Detection of Antibiotics: An Overview of the Past Decade.Nanomaterials (Basel, Switzerland) · 2021Review
- Electrochemical assay of ampicillin using FeMikrochimica acta · 2020Article
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
Two kinds of aptasensors for ampicillin (AMP) are described. The assay strategies include the use of gold nanoparticles (AuNPs) that were modified with (a) a thiolated aptamer (T-Apt), and (b) a non-thiolated polyadenine aptamer (polyA Apt). The AuNPs and the aptamers were brought to interaction prior to addition of AMP. T-Apt and polyA Apt are adsorbed on the AuNPs by different mechanisms. The adsorbed aptamer was able to bind the target while preventing non-specific interactions. Remarkably different optical absorbances (measured at 520 and 680 nm) are produced the absence and presence of AMP. The assay can selectively recognize AMP even in the presence of species of similar chemical structure. The T-Apt based assay has a linear response in the 1-600 nM AMP concentration range and a 0.1 nM limit of detection. The respective data for the polyA Apt assay are 1-400 nM and 0.49 nM. Graphical abstract Schematic presentation of the colorimetric aptasensor for ampicillin detection using two kinds of anti-ampicillin aptamers and gold nanoparticles. Polydiallyldimethylammonium chloride (PDDA) acts as aggregation agent.
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