ArticlePediatric cardiology2019
Impact of Obesity on Left Ventricular Thickness in Children with Hypertrophic Cardiomyopathy.
Article in Pediatric cardiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- Exercise and Sport Participation in Pediatric Hypertrophic Cardiomyopathy: A Changing Paradigm.Current treatment options in cardiovascular medicine · 2026Review
- The global burden of cardiovascular diseases attributable to high body mass index, 1990-2023.Frontiers in cardiovascular medicine · 2026Article
- Modifiable Health Behaviours in Children with HCM: Lessons from the Heart Health Survey.Pediatric cardiology · 2026Article
- Exploring Health-Related Quality of Life in Children With Hypertrophic Cardiomyopathy and Relationship to Physical Activity.Journal of the American Heart Association · 2024Observational
- Insulin resistance, C-reactive protein, diastolic to systolic blood pressure ratio and epicardial fat are related to sedentary time, and inversely related to physical activity in school-aged children.Frontiers in public health · 2024Article
- The weight of obesity in hypertrophic cardiomyopathy.Clinical medicine (London, England) · 2023Review
- Sex Differences in Hypertrophic Cardiomyopathy: Interaction With Genetics and Environment.Current heart failure reports · 2021Review
- Obesity cardiomyopathy: evidence, mechanisms, and therapeutic implications.Physiological reviews · 2021Review
- Discordant clinical features of identical hypertrophic cardiomyopathy twins.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- TGF-β: The missing link in obesity-associated airway diseases?Current research in pharmacology and drug discovery · 2021Review
- Unraveling the Genotype-Phenotype Relationship in Hypertrophic Cardiomyopathy: Obesity-Related Cardiac Defects as a Major Disease Modifier.Journal of the American Heart Association · 2020Review
- Echocardiographic assessment of cardiac function abnormalities and related risk factors in Thai overweight and obese children.Annals of pediatric cardiologyArticle
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Authors and funding
37 authors at 20 institutions in 6 countries.
Funding
Abstract
Obesity is associated with additional left ventricular hypertrophy (LVH) in adults with hypertrophic cardiomyopathy (HCM). It is not known whether obesity can lead to further LVH in children with HCM. Echocardiographic LV dimensions were determined in 504 children with HCM. Measurements of interventricular septal thickness (IVST) and posterior wall thickness (PWT), and patients' weight and height were recorded. Obesity was defined as a body mass index (BMI) ≥ 99th percentile for age and sex. IVST data was available for 498 and PWT data for 484 patients. Patient age ranged from 2 to 20 years (mean ± SD, 12.5 ± 3.9) and 340 (68%) were males. Overall, patient BMI ranged from 7 to 50 (22.7 ± 6.1). Obesity (BMI 18-50, mean 29.1) was present in 140 children aged 2-19.6 (11.3 ± 4.1). The overall mean IVST was 20.5 ± 9.6 mm and the overall mean PWT was 11.0 ± 8.4 mm. The mean IVST in the obese patients was 21.6 ± 10.0 mm and mean PWT was 13.3 ± 14.7 mm. The mean IVST in the non-obese patients was 20.1 ± 9.5 mm and mean PWT was 10.4 ± 4.3 mm. Obesity was not significantly associated with IVST (p = 0.12), but was associated with increased PWT (0.0011). Obesity is associated with increased PWT but not IVST in children with HCM. Whether obesity and its impact on LVH influences clinical outcomes in children with HCM needs to be studied.
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Registered trials
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