ArticleBMJ paediatrics open2019
Recurrent maternal CMV infection associated with symptomatic congenital infection: results from a questionnaire study in Portugal.
Article in BMJ paediatrics open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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4 authors at 3 institutions in 3 countries.
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No grant is acknowledged in the PubMed record.
Abstract
objectiveHuman cytomegalovirus (CMV) is the most widespread agent of congenital infection in humans and is still a challenging issue. Despite lower rates of vertical transmission being associated with recurrent infection when compared with primary infection, the first still represents the majority of congenital infections worldwide. Based on data from active reporting, we explored the influence of maternal primary/non-primary infection both on the presentation and outcome of congenital CMV infection in early childhood.
designInfants with positive viruria during the first 3 weeks of life were reported through the Portuguese Paediatric Surveillance Unit. PATIENTS: Infants born between 2006 and 2011 with confirmed congenital CMV infection.
methodsMaternal infection was considered primary if CMV IgG seroconversion occurred during pregnancy or low avidity IgG was documented; it was considered non-primary if positive IgG was documented before pregnancy or high avidity CMV IgG was present early in pregnancy. Follow-up questionnaires were sent up to 6 years of age.
resultsForty confirmed cases of congenital CMV infection were reported (6.6:10
conclusionThe reported number of confirmed cases of congenital CMV infection was much lower than expected. Under-reporting and missed diagnosis were considered possible reasons. Non-primary maternal infections were associated with symptomatic congenital CMV infection in the offspring. Maternal recurrent infections can have a significant impact on the total number of symptomatic infections in Portugal.
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