Evidence map›Paper›PMID 31263785›Full record

ArticleCommunications biology2019

Structural basis for cooperativity of human monoclonal antibodies to meningococcal factor H-binding protein.

Ilaria Peschiera, Maria Giuliani, Fabiola Giusti, Roberto Melero, Eugenio Paccagnini, Danilo Donnarumma, Werner Pansegrau, José M Carazo, Carlos O S Sorzano, Maria Scarselli and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Evaluation of pharyngeal carriage ofNew microbes and new infections · 2022
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ilaria Peschiera1Centro National de Biotecnologia, 28049 Madrid, Spain.
Maria GiulianiGSK Vaccines Srl, 53100 Siena, Italy.
Fabiola GiustiGSK Vaccines Srl, 53100 Siena, Italy.
Roberto Melero1Centro National de Biotecnologia, 28049 Madrid, Spain.
Eugenio Paccagnini3Department of Life Sciences, University of Siena, 53100 Siena, Italy.ORCID 0000-0002-9784-2057
Danilo DonnarummaGSK Vaccines Srl, 53100 Siena, Italy.
Werner PansegrauGSK Vaccines Srl, 53100 Siena, Italy.
José M Carazo1Centro National de Biotecnologia, 28049 Madrid, Spain.
Carlos O S Sorzano1Centro National de Biotecnologia, 28049 Madrid, Spain.ORCID 0000-0002-9473-283X
Maria ScarselliGSK Vaccines Srl, 53100 Siena, Italy.
Vega MasignaniGSK Vaccines Srl, 53100 Siena, Italy.
Lassi J Liljeroos4Roche, 02180 Espoo, Finland.
Ilaria FerlenghiGSK Vaccines Srl, 53100 Siena, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Monoclonal antibody (mAb) cooperativity is a phenomenon triggered when mAbs couples promote increased bactericidal killing compared to individual partners. Cooperativity has been deeply investigated among mAbs elicited by factor H-binding protein (fHbp), a

Indexed as

Antibodies, MonoclonalAntigens, BacterialBacterial ProteinsBlood Bactericidal ActivityComplement Factor HEpitope MappingHumansMeningococcal VaccinesMicroscopy, Electron, TransmissionSurface Plasmon ResonanceAntibodies, MonoclonalAntigens, BacterialBacterial ProteinsCFH protein, humanComplement Factor Hfactor H-binding protein, Neisseria meningitidisMeningococcal VaccinesCryoelectron microscopyCryoelectron tomographyMeningitis

Identifiers

PMID31263785
PMCPMC6595007

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.