Evidence map›Paper›PMID 31263776›Full record

ArticleCommunications biology2019

GABA in the suprachiasmatic nucleus refines circadian output rhythms in mice.

Daisuke Ono, Ken-Ichi Honma, Yuchio Yanagawa, Akihiro Yamanaka, Sato Honma

Abstract read
In one paragraph

Article in Communications biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Integrating Astrocytes in the Sleep-Wake Cycle: The Time Is Now.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
  5. Review
  6. Article
  7. Article
  8. GABAProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  9. Review
  10. Expression of the vesicular GABA transporter within neuromedin SProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  11. Review
  12. Review
  13. Review
  14. Astrocytic control of extracellular GABA drives circadian timekeeping in the suprachiasmatic nucleus.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  15. Disturbances of Hormonal Circadian Rhythms by Light Pollution.International journal of molecular sciences · 2023
    Review
  16. Article
  17. Article
  18. Article
  19. Circadian clock and temporal meal pattern.Medical review (2021) · 2023
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Daisuke Ono1Department of Neuroscience II, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601 Japan.
Ken-Ichi Honma3Research and Education Center for Brain Science, Hokkaido University Graduate School of Medicine, Sapporo, 060-8638 Japan.
Yuchio Yanagawa4Department of Genetic and Behavioral Neuroscience, Gunma University Graduate School of Medicine, Maebashi, Gunma 371-8511 Japan.
Akihiro Yamanaka1Department of Neuroscience II, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601 Japan.
Sato Honma3Research and Education Center for Brain Science, Hokkaido University Graduate School of Medicine, Sapporo, 060-8638 Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In mammals, the circadian rhythms are regulated by the central clock located in the hypothalamic suprachiasmatic nucleus (SCN), which is composed of heterogeneous neurons with various neurotransmitters. Among them an inhibitory neurotransmitter, γ-Amino-Butyric-Acid (GABA), is expressed in almost all SCN neurons, however, its role in the circadian physiology is still unclear. Here, we show that the SCN of fetal mice lacking vesicular GABA transporter (VGAT

Indexed as

AnimalsCalciumCircadian Rhythmgamma-Aminobutyric AcidGlutamate DecarboxylaseMicePeriod Circadian ProteinsSignal TransductionSuprachiasmatic NucleusVesicular Inhibitory Amino Acid Transport ProteinsCalciumgamma-Aminobutyric AcidGlutamate Decarboxylaseglutamate decarboxylase 2Per2 protein, mousePeriod Circadian ProteinsVesicular Inhibitory Amino Acid Transport ProteinsViaat protein, mouseCircadian regulationNeurophysiology

Identifiers

PMID31263776
PMCPMC6588595

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.