ReviewACS central science2019
Enhanced Diffusion of Catalytically Active Enzymes.
Review in ACS central science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 79 citations in OpenAlex.
- DNA-Enzyme Hybrid Nanostructures: Functional Materials to Modulate Enzymatic Activity.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- Programmable Nanoscale Motion via Molecular Patterning on DNA Origami.Angewandte Chemie (International ed. in English) · 2026Article
- Biomimetic Cobalt Complex Stabilized by Hydrogel on High-Edge-Density Graphite for ORR and HER in Quiescent Solutions.Langmuir : the ACS journal of surfaces and colloids · 2025Article
- Sticky enzymes: increased metabolic efficiency via substrate-dependent enzyme clustering.PRX life · 2025Article
- A Model-Driven Approach to Assessing the Fouling Mechanism in the Crossflow Filtration of Laccase Extract fromMembranes · 2025Article
- Technology Roadmap of Micro/Nanorobots.ACS nano · 2025Review
- Super-Resolution Mapping and Quantification of Molecular Diffusion via Single-Molecule Displacement/Diffusivity Mapping (SMAccounts of chemical research · 2025Article
- Force Generation by Enhanced Diffusion in Enzyme-Loaded Vesicles.Nano letters · 2025Article
- Impact of Ligand-Induced Oligomer Dissociation on Enzyme Diffusion, Directly Observed at the Single-Molecule Level.Nano letters · 2025Article
- Nonthermal fluctuations accelerate biomolecular motors.Biophysical reviews · 2024Review
- Exploring Emergent Properties in Enzymatic Reaction Networks: Design and Control of Dynamic Functional Systems.Chemical reviews · 2024Review
- SARS-CoV-2 proteases Mpro and PLpro: Design of inhibitors with predicted high potency and low mammalian toxicity using artificial neural networks, ligand-protein docking, molecular dynamics simulations, and ADMET calculations.Computers in biology and medicine · 2023Article
- Dependence of diffusion ineLife · 2022Article
- Enzyme Purification Improves the Enzyme Loading, Self-Propulsion, and Endurance Performance of Micromotors.ACS nano · 2022Article
- Displacement Statistics of Unhindered Single Molecules Show no Enhanced Diffusion in Enzymatic Reactions.Journal of the American Chemical Society · 2022Article
- Molecular Diffusivity of Click Reaction Components: The Diffusion Enhancement Question.Journal of the American Chemical Society · 2022Article
- Pnictogen-Bonding Catalysis and Transport Combined: Polyether Transporters Made In Situ.JACS Au · 2021Article
- Single-particle diffusional fingerprinting: A machine-learning framework for quantitative analysis of heterogeneous diffusion.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Chemically-powered swimming and diffusion in the microscopic world.Nature reviews. Chemistry · 2021Review
- Single-molecule diffusometry reveals no catalysis-induced diffusion enhancement of alkaline phosphatase as proposed by FCS experiments.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The past decade has seen an increasing number of investigations into enhanced diffusion of catalytically active enzymes. These studies suggested that enzymes are actively propelled as they catalyze reactions or bind with ligands (e.g., substrates or inhibitors). In this Outlook, we chronologically summarize and discuss the experimental observations and theoretical interpretations and emphasize the potential contradictions in these efforts. We point out that the existing multimeric forms of enzymes or isozymes may cause artifacts in measurements and that the conformational changes upon substrate binding are usually not sufficient to give rise to a diffusion enhancement greater than 30%. Therefore, more rigorous experiments and a more comprehensive theory are urgently needed to quantitatively validate and describe the enhanced enzyme diffusion.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.