ReviewFrontiers in nutrition2019
Obesity Alters the Muscle Protein Synthetic Response to Nutrition and Exercise.
Review in Frontiers in nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The Association between Dietary Inflammatory Index and Aging Biomarkers/Conditions: A Systematic Review and Dose-response Meta-analysis.The journal of nutrition, health & aging · 2023Pooled it
- The Effects of Dietary Protein Supplementation on Acute Changes in Muscle Protein Synthesis and Longer-Term Changes in Muscle Mass, Strength, and Aerobic Capacity in Response to Concurrent Resistance and Endurance Exercise in Healthy Adults: A Systematic Review.Sports medicine (Auckland, N.Z.) · 2022Pooled it
- Systematic review and meta-analysis of protein intake to support muscle mass and function in healthy adults.Journal of cachexia, sarcopenia and muscle · 2022Pooled it
- Oral Multienzyme Supplementation Alters Postprandial Plasma Nutrient Concentrations after a Mixed Meal in Healthy Middle-Aged and Older Adults: A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial.The Journal of nutrition · 2026Trial
- Correlation between physiological and biochemical variables during short term adequate protein intake combined with resistance exercise in sedentary adults.Scientific reports · 2025Trial
- Clinical (BMI and MRI) and Biochemical (Adiponectin, Leptin, TNF-α, and IL-6) Effects of High-Intensity Aerobic Training with High-Protein Diet in Children with Obesity Following COVID-19 Infection.International journal of environmental research and public health · 2022Trial
- A randomized clinical trial on the effects of exercise on muscle remodelling following bariatric surgery.Journal of cachexia, sarcopenia and muscle · 2021Trial
- Vitamin DJournal of cachexia, sarcopenia and muscle · 2021Trial
- Restoration of circadian rhythm as novel targets against sarcopenia.Chinese medical journal · 2026Review
- Amino Acid-Stimulated Muscle Protein Synthesis is Attenuated During Early Recovery from Aerobic Exercise in Individuals with Obesity.bioRxiv : the preprint server for biology · 2026Article
- Sarcopenia and Frailty in COPD: Mechanisms, Relationship with Malnutrition and Potential Therapeutic Interventions.Nutrients · 2026Review
- Voluntary wheel running attenuates peptidoglycan-polysaccharide-induced inflammation and preserves skeletal muscle remodeling in male C57BL/6J mice.Physiological reports · 2026Article
- Influence of Exercise on Proteolysis-Related Markers of Cardiac, Renal, and Endothelial Dysfunction.Cureus · 2026Article
- Dietary restriction and aerobic exercise alleviate obesity-related skeletal muscle impairment via the miR-130/PPARγ axis and IGF-1/Akt/mTOR signaling activation.Scientific reports · 2026Article
- Nutrition's role in extending healthspan: CRN-international symposium report.European journal of nutrition · 2026Article
- Machine learning evaluation of the discriminative ability of Castelli Risk Index-I and other non-traditional lipid indices for sarcopenia: a cross-sectional study based on CHARLS.Lipids in health and disease · 2026Article
- Effect of FATmax-Intensity Exercise on Body Composition and Cardiovascular Health in Overweight and Obese Individuals: A Systematic Review and Meta-Analysis.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Review
- Gestational Obesity Impairs Maternal Glucose Metabolism in Post-Partum Ewes.Animals : an open access journal from MDPI · 2025Article
- Impact of Abdominal Obesity on Frailty Development: A Web-Based Survey Using a Smartphone Health App.Geriatrics (Basel, Switzerland) · 2025Article
- Non-Targeted Metabolomics Analysis of Metabolic Differences Between Different Concentrations of Protein Diets in the Longest Dorsal Muscle of Tibetan Pigs.Metabolites · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Improving the health of skeletal muscle is an important component of obesity treatment. Apart from allowing for physical activity, skeletal muscle tissue is fundamental for the regulation of postprandial macronutrient metabolism, a time period that represents when metabolic derangements are most often observed in adults with obesity. In order for skeletal muscle to retain its capacity for physical activity and macronutrient metabolism, its protein quantity and composition must be maintained through the efficient degradation and resynthesis for proper tissue homeostasis. Life-style behaviors such as increasing physical activity and higher protein diets are front-line treatment strategies to enhance muscle protein remodeling by primarily stimulating protein synthesis rates. However, the muscle of individuals with obesity appears to be resistant to the anabolic action of targeted exercise regimes and protein ingestion when compared to normal-weight adults. This indicates impaired muscle protein remodeling in response to the main anabolic stimuli to human skeletal muscle tissue is contributing to poor muscle health with obesity. Deranged anabolic signaling related to insulin resistance, lipid accumulation, and/or systemic/muscle inflammation are likely at the root of the anabolic resistance of muscle protein synthesis rates with obesity. The purpose of this review is to discuss the impact of protein ingestion and exercise on muscle protein remodeling in people with obesity, and the potential mechanisms underlining anabolic resistance of their muscle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.