Evidence map›Paper›PMID 31263558›Full record

ArticleLight, science & applications2019

MEMS-in-the-lens architecture for a miniature high-NA laser scanning microscope.

Tianbo Liu, Milind Rajadhyaksha, David L Dickensheets

Abstract read
In one paragraph

Article in Light, science & applications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Tianbo Liu1Electrical and Computer Engineering Department, Montana State University, Bozeman, MT 59715 USA.ORCID 0000-0003-0474-419X
Milind Rajadhyaksha2Dermatology Department, Memorial Sloan Kettering Cancer Center, New York, NY 10022 USA.
David L Dickensheets1Electrical and Computer Engineering Department, Montana State University, Bozeman, MT 59715 USA.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Sensitivity and specificity of line-scanning versus point-scanning reflectance confocal microscopy for detecting melanocytic skin lesions in vivoR01CA201399 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI FOX, WILLIAM J., RAJADHYAKSHA, MILIND · 2016 to 2019
$2.1M
Integrated wide-field imaging and confocal microscopy with agile 3D beam scanningR21EB018507 · NIBIB · MONTANA STATE UNIVERSITY - BOZEMAN · PI DICKENSHEETS, DAVID LEE, RAJADHYAKSHA, MILIND · 2014 to 2015
$421k
NCI NIH HHS P30 CA008748NIBIB NIH HHS R21 EB018507
6 · The paper itself

Abstract

Laser scanning microscopes can be miniaturized for in vivo imaging by substituting optical microelectromechanical system (MEMS) devices in place of larger components. The emergence of multifunctional active optical devices can support further miniaturization beyond direct component replacement because those active devices enable diffraction-limited performance using simpler optical system designs. In this paper, we propose a catadioptric microscope objective lens that features an integrated MEMS device for performing biaxial scanning, axial focus adjustment, and control of spherical aberration. The MEMS-in-the-lens architecture incorporates a reflective MEMS scanner between a low-numerical-aperture back lens group and an aplanatic hyperhemisphere front refractive element to support high-numerical-aperture imaging. We implemented this new optical system using a recently developed hybrid polymer/silicon MEMS three-dimensional scan mirror that features an annular aperture that allows it to be coaxially aligned within the objective lens without the need for a beam splitter. The optical performance of the active catadioptric system is simulated and imaging of hard targets and human cheek cells is demonstrated with a confocal microscope that is based on the new objective lens design.

Indexed as

Adaptive opticsConfocal microscopy

Identifiers

PMID31263558
PMCPMC6592906

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.