ArticleInterface focus2019
Smooth muscle regional contribution to vaginal wall function.
Article in Interface focus, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed.
- Biomechanical function of the murine cervix with elastic fiber deficiency.Journal of the mechanical behavior of biomedical materials · 2026Article
- Spectral photoacoustic imaging of age-related reproductive tract collagen changes in a mouse model of prolapse.Photoacoustics · 2026Article
- Histological and transcriptomic analysis of paravaginal and central defects in anterior vaginal wall prolapse: Insights from DeLancey's pelvic floor theory.Histology and histopathology · 2025Article
- Vaginal biomechanical function in premenopausal and postmenopausal women with and without pelvic organ prolapse.Scientific reports · 2025Article
- Biomechanical and Compositional Changes in the Murine Uterus with Age.Annals of biomedical engineering · 2025Article
- Functional outcome of the anterior vaginal wall in a pelvic surgery injury rat model after treatment with stem cell-derived progenitors of smooth muscle cells.Stem cell research & therapy · 2024Article
- Functional outcome of the anterior vaginal wall in a pelvic surgery injury rat model after treatment with stem cell-derived progenitors of smooth muscle cells.Research square · 2024Article
- Biophysical Mechanisms of Vaginal Smooth Muscle Contraction: The Role of the Membrane Potential and Ion Channels.Pathophysiology : the official journal of the International Society for Pathophysiology · 2024Review
- Exploring myometrial microenvironment changes at the single-cell level from nonpregnant to term pregnant states.Physiological genomics · 2024Article
- Multiparity Reduces Urethral and Vaginal Pressures Following the Bulboglandularis Muscle Stimulation in Rabbits.Reproductive sciences (Thousand Oaks, Calif.) · 2023Article
- Single-cell transcriptomic data reveal the increase in extracellular matrix organization and antigen presentation abilities of fibroblasts and smooth muscle cells in patients with pelvic organ prolapse.International urogynecology journal · 2023Article
- Release Kinetics of Metronidazole from 3D Printed Silicone Scaffolds for Sustained Application to the Female Reproductive Tract.Biomedical engineering advances · 2023Article
- Smooth muscle contribution to vaginal viscoelastic response.Journal of the mechanical behavior of biomedical materials · 2023Article
- Article
- Advances in vaginal bioengineering: Applications, techniques, and needs.Current research in physiology · 2023Review
- scRNA-seq reveals aging-related immune cell types and regulators in vaginal wall from elderly women with pelvic organ prolapse.Frontiers in immunology · 2023Article
- Long-term menopause exacerbates vaginal wall support injury in ovariectomized rats by regulating amino acid synthesis and glycerophospholipid metabolism.Frontiers in endocrinology · 2023Article
- Biaxial Murine Vaginal Remodeling With Reproductive Aging.Journal of biomechanical engineering · 2022Article
- Smooth Muscle Organization and Nerves in the Rat Vagina: A First Look Using Tissue Clearing and Immunolabeling.Annals of biomedical engineering · 2022Article
- Role of fibulin-5 insufficiency and prolapse progression on murine vaginal biomechanical function.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Pelvic organ prolapse is characterized as the descent of the pelvic organs into the vaginal canal. In the USA, there is a 12% lifetime risk for requiring surgical intervention. Although vaginal childbirth is a well-established risk factor for prolapse, the underlying mechanisms are not fully understood. Decreased smooth muscle organization, composition and maximum muscle tone are characteristics of prolapsed vaginal tissue. Maximum muscle tone of the vaginal wall was previously investigated in the circumferential or axial direction under uniaxial loading; however, the vaginal wall is subjected to multiaxial loads. Further, the contribution of vaginal smooth muscle basal (resting) tone to mechanical function remains undetermined. The objectives of this study were to determine the contribution of smooth muscle basal and maximum tone to the regional biaxial mechanical behaviour of the murine vagina. Vaginal tissue from C57BL/6 mice was subjected to extension-inflation protocols (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.