ArticleFrontiers in physiology2019
Cardiopulmonary Responses to Sub-Maximal Ergometer Exercise in a Hypo-Gravity Analog Using Head-Down Tilt and Head-Up Tilt.
Article in Frontiers in physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Dose-dependent effects of graded altered gravity during hypovolaemia on central haemodynamics and cardiovascular autonomic regulation.Experimental physiology · 2026Article
- Hypogravity simulation using the Variable Gravity Suspension System: A technical report.Experimental physiology · 2026Article
- Ocular perfusion pressure is not reduced in response to lower body negative pressure.NPJ microgravity · 2024Article
- Gravitational effects on carotid and jugular characteristics in graded head-up and head-down tilt.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Indirect measurement of absolute cardiac output during exercise in simulated altered gravity is highly dependent on the method.Journal of clinical monitoring and computing · 2022Article
- Gravitational Dose-Response Curves for Acute Cardiovascular Hemodynamics and Autonomic Responses in a Tilt Paradigm.Journal of the American Heart Association · 2022Article
- Virtual Reality "exergames": A promising countermeasure to improve motivation and restorative effects during long duration spaceflight missions.Frontiers in physiology · 2022Article
- Artificially altered gravity elicits cell homeostasis imbalance in planarian worms, and cerium oxide nanoparticles counteract this effect.Journal of biomedical materials research. Part A · 2021Article
- Modeling individual differences in cardiovascular response to gravitational stress using a sensitivity analysis.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- The Influence of Altered-Gravity on Bimanual Coordination: Retention and Transfer.Frontiers in physiology · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
After more than 50 years of spaceflight, we still do not know what is the appropriate range of gravity levels that are required to maintain normal physiological function in humans. This research effort aimed to investigate musculoskeletal, cardiovascular, and pulmonary responses between 0 and 1 g. A human experiment was conducted to investigate acute physiological outcomes to simulated altered-gravity with and without ergometer exercise using a head-down tilt (HDT)/head-up tilt (HUT) paradigm. A custom tilting platform was built to simulate multiple gravitational loads in the head-to-toe direction (Gz) by tilting the bed to the appropriate angle. Gravity levels included: Microgravity (-6°HDT), Moon (0.17g-Gz at +9.5°HUT), Mars (0.38g-Gz at +22.3°HUT), and Earth (1g-Gz at +90° upright). Fourteen healthy subjects performed an exercise protocol at each simulated gravity level that consisted of three work rates (50W, 75W, 100W) while maintaining a constant cycling rate of 90 rpm. Multiple cardiopulmonary variables were gathered, including volume of oxygen uptake (VO
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