Evidence map›Paper›PMID 31263423›Full record

ArticleFrontiers in physiology2019

Lactic Acid Accumulation During Exhaustive Exercise Impairs Release of Neutrophil Extracellular Traps in Mice.

Yue Shi, Hui Shi, David C Nieman, Qiongyi Hu, Luyu Yang, Tingting Liu, Xiaofeng Zhu, Hongzhan Wei, Die Wu, Fei Li and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Skeletal Muscle and the Immune System.Advances in experimental medicine and biology · 2025
    Review
  5. Review
  6. Review
  7. Acta pharmaceutica Sinica. B · 2022
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Mouse Fitness as Determined Through Treadmill Running and Walking.Methods in molecular biology (Clifton, N.J.) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Yue ShiSchool of Kinesiology, Shanghai University of Sport, Shanghai, China.
Hui ShiDepartment of Rheumatology and Immunology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
David C NiemanHuman Performance Laboratory, Appalachian State University, North Carolina Research Campus, Kannapolis, NC, United States.
Qiongyi HuDepartment of Rheumatology and Immunology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Luyu YangDepartment of General Surgery, Huashan Hospital, Cancer Metastasis Institute, Fudan University, Shanghai, China.
Tingting LiuDepartment of Rheumatology and Immunology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xiaofeng ZhuNormal College, Jiaxing University, Jiaxing, China.
Hongzhan WeiSchool of Kinesiology, Shanghai University of Sport, Shanghai, China.
Die WuSchool of Kinesiology, Shanghai University of Sport, Shanghai, China.
Fei LiSchool of Kinesiology, Shanghai University of Sport, Shanghai, China.
Yanqiu CuiSchool of Kinesiology, Shanghai University of Sport, Shanghai, China.
Peijie ChenSchool of Kinesiology, Shanghai University of Sport, Shanghai, China.
Shanghai University of Sport · CNShanghai Jiao Tong University · CNAppalachian State University · USHuashan Hospital · CNJiaxing University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lactic acid (LA) is a sensitive indicator of exercise intensity and duration. A single bout of prolonged and intensive exercise can cause transient immunosuppression through the interaction of cellular, humoral, and hormone factors. Exercise-induced influences on neutrophil extracellular traps (NETs) release have been reported, but the underlying mechanism is unknown. This study investigated NETs release, cell-free DNA (cf-DNA), and LA concentration in mice after 60 and 145 min of intensive, graded treadmill running. The concentration of LA and cf-DNA increased, while the level of myeloperoxidase-DNA (MPO-DNA) (an indicator of NETs release) decreased during 145 min of exhaustive running. LA was positively and negatively correlated with cf-DNA and MPO-DNA (

Indexed as

cell-free DNAexhaustive exerciselactic acidneutrophil extracellular trapsROS

Identifiers

PMID31263423
PMCPMC6585869
OpenAlexW2952233927

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.