Evidence map›Paper›PMID 31263412›Full record

ArticleFrontiers in pharmacology2019

Desensitization of cAMP Accumulation via Human β3-Adrenoceptors Expressed in Human Embryonic Kidney Cells by Full, Partial, and Biased Agonists.

Katerina Okeke, Martina B Michel-Reher, Stavros Gravas, Martin C Michel

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Concentration-dependent alphaFrontiers in pharmacology · 2021
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Katerina OkekeDepartment of Pharmacology, Johannes Gutenberg University Mainz, Mainz, Germany.
Martina B Michel-ReherDepartment of Pharmacology, Johannes Gutenberg University Mainz, Mainz, Germany.
Stavros GravasDepartment of Urology, University of Thessaly, Larissa, Greece.
Martin C MichelDepartment of Pharmacology, Johannes Gutenberg University Mainz, Mainz, Germany.
Johannes Gutenberg University Mainz · DEUniversity of Thessaly · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

β

Indexed as

biased agonismcAMPdesensitizationextracellular signal-related kinasepartial agonismβ3-adrenoceptor

Identifiers

PMID31263412
PMCPMC6590479
OpenAlexW2948156973

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.